阿昔洛韦治疗慢性乙型肝炎临床研究

目的 通过不同治疗方案观察阿昔洛韦对慢性乙型肝炎的治疗作用，并评价具有生和安全必地４６０例慢性乙型肝炎患随要分为高、中、低三个剂量组。低剂量组加聚肌胞，疗程２个月，随访３个月～１年。观察治疗前后患的肝、肾功能、ＨＢＶＭ及血尿常规，临床表现及不良反应。结果 ＨＢｅＡｇ、ＨＢＶ－ＤＮＡ阴转率分别为４０％～６０％、４３％、６６％，ＡＬＴ复常率为６０％～６５％，伴药后３个月～１年同无变化。结论 阿昔洛

Clinical study on chronical B virus hepatitis treated with Aciclovir

Purpose To observe the effect of Aciclovir on chronical B virus hepatitis,and assess its efficience and safety.Methods 460 cases of chronical B rirus hepatitis were randomly divided into high,middle and low dose groups,adding polyinosinic polycytidylic acid to low group.They were treated two months and followed up three months to one year.The function of liver and kidney,HBVM,routine of blood and urine were examined.Clinical demonstration and adverse effects were observed.Results The negative rate of HBeAg and HBV DNA were respectively 40%~60% and 43%~66%.The rate of resuming of ALT was 60%~65%.There was no change after three months to one year.Conclusions The effect of Aciclovir was steady.Middle dose can abtain satisfactory effect.The adverse effect was 1ess and slighter.No severe poison effect was discoveried.