喉咽癌手术放疗后甲状腺功能减退

本文对４２例喉咽癌手术及放疗后患者甲状腺功能的变化的初步探讨表明：在治疗结束后不同时间内有５７．１％的患者Ｔ４降低及（或）ＴＳＨ升高，其中放疗结合甲状腺部分切除者其发生率高达７３．９％，而未行甲状腺部分切除者仅３８．５％，两者呈显著差异（Ｐ＝０．０３）。术前或术后放疗对甲状腺功能影响较小，亦无明显差异。发生时间在治疗结束后２年内尤其在１年左右为多见。

Hypothyroidism following radiation and surgery for hypopharyngeal carcinoma

Forty-two patients with hypopharyngeal carcinoma were studied to determine the effect of radiotherapy and surgery on thyroid function.The serum T4 and TSH levels were obtained as a screening test for hypothyroidism. The results showed that elevated TSH and/or lowered T4 level were found in 24 of the 42 cases(57.1%).The highest incidence of hypothyroidism(73.9%) occurred in the group treated with combined radiation with surgry including hemithyroidectomy as compared with those who did not undergo hemithyroidectomy(P=0.03).The thyroid function saw little difference before and after operative radiation and no obvious change in thyroid function was detected in the group treated with simple radiatien. Most hypothyoidism developed in 2 years after treatment.