心痛宁胶囊治疗冠状动脉痉挛阳虚血瘀证患者高敏C反应蛋白水平的观察

目的 观察心痛宁胶囊治疗冠状动脉痉挛(CAS)阳虚血瘀证患者高敏C反应蛋白(hs-CRP)水平.方法 随机将64例CAS阳虚血瘀证的患者分为治疗组(36例)和对照组(28例).治疗组服用心痛宁胶囊,每次5粒,每日3次;对照组口服盐酸贝尼地平(商品名:可力洛)4 mg,每日1次.4周后对比两组治疗前后心绞痛程度半定量计分、硝酸甘油用量、心电图、hs-CRP水平变化.结果 治疗组心绞痛程度半定量计分、硝酸甘油用量、hs-CRP水平均低于对照组(P＜0.05),但在改善心电图心肌缺血改变方面,与对照组无统计学意义.结论 心痛宁胶囊治疗CAS阳虚血瘀证优于盐酸贝尼地平.

Effect of Xintongning Capsule on hs-CRP in Coronary Artery Spasm with Yang-deficiency and Blood Stasis Syndrome

Objective To investigate the effect of Xintongning capsule on high-sensitivity C-reactive protein(hs-CRP)levels in coronary artery spasm(CAS) with yang-deficiency and blood stasis syndrome.Methods Sixty-four patients(pts) with CAS and yang-deficiency blood stasis syndrome were randomly divided into treatment group(n=36) treated with Xintongning capsules and control group(n=28) treated with hydrochloride benidipine for 4 weeks.The semi-quantitative scores of angina,nitroglycerin consumption,electrocardiogram(ECG),and hs-CRP levels were compared for two groups before and after treatment.Results The semi-quantitative scores of angina,nitroglycerin consumption,hs-CRP levels in the treatment group were lower than that in the control group(P<0.05).There was no significant difference in ECG of myocardial ischemia between two groups(P>0.05).Conclusion Xintongning capsule is better than hydrochloride benidipine for CAS with yang-deficiency and blood stasis syndrome.