18F-FDG和18F-FET PET-CT检查致受检者辐射剂量研究

目的 估算接受¹⁸F-FDG(¹⁸F-2-deoxy-D-glucose)和¹⁸F-FET(O-2-¹⁸F-fluoroethyl-L-tyrosine)PET-CT全身检查受检者的有效剂量和器官剂量。方法 使用两种PET-CT扫描协议进行全身显像。PET部分的有效剂量和器官剂量利用基于医学内照射剂量(Medical Internal Radiation Dose, MIRD)计算模式的计算程序IDAC 2.1进行计算，CT部分的有效剂量和器官剂量利用VirtualDose软件计算，PET和CT剂量之和为受检者总的有效剂量。结果 在常规PET-CT扫描中，男性受检者受¹⁸F-FDG辐射所致的有效剂量为(4.81 ±1.04) mSv，女性受检者为(6.09 ±0.73) mSv；男性受检者受¹⁸F-FET辐射所致的有效剂量为(2.67 ±0.38) mSv，女性受检者为(3.21 ±0.38) mSv；CT部分男性受检者的有效剂量为(5.63 ±0.32) mSv，女性受检者为(5.51 ±0.29) mSv。¹⁸F-FDG PET-CT检查男性和女性受检者所受总有效剂量分别为(10.44 ±1.09) mSv和(11.60 ±0.79) mSv。¹⁸F-FET PET-CT检查总有效剂量分别为(8.30 ±0.50) mSv和(8.72 ±0.49) mSv。在诊断性CT扫描中，CT扫描致男性受检者的有效剂量为(16.28 ±1.01) mSv，女性受检者为(13.49 ±0.72) mSv；¹⁸F-FDG PET-CT检查男性和女性受检者总有效剂量分别为(21.09 ±1.45) mSv和(19.58 ±1.03) mSv。¹⁸F-FET PET-CT检查总有效剂量分别为(18.95 ±1.08) mSv和(16.70 ±0.81) mSv。结论 不同的PET-CT扫描参数致受检者受到不同大小的辐射剂量，在日常工作中应根据受检者的实际情况，优化PET和CT的采集参数，降低受检者剂量，实践辐射防护最优化。

Research on patient dose in 18F-FDG and 18F-FET PET-CT examinations

Objective To estimate the effective and organ dose of patients receiving the ¹⁸F-FDG (¹⁸F-2-deoxy-D-glucose) and ¹⁸F-FET (O-2-¹⁸F- fluoroethyl -L-tyrosine) PET-CT whole body examinations.Methods Two PET-CT scanning protocols were used for whole body imaging. The effective and organ dose of PET part were calculated using the internal dose computer program IDAC 2.1 based on MIRD method. The effective and organ doses of CT part were calculated by VirtualDose software, and the sum of CT and PET dose was the total effective dose of patients.Results In the conventional PET-CT scan protocol, the effective dose was (4.81 ±1.04) mSv for male and (6.09 ±0.73) mSv for female patients from ¹⁸F-FDG; the effective dose was (2.67 ±0.38) mSv for male and (3.21 ±0.38) mSv for female patients from ¹⁸F-FET; the effective dose was (5.63 ±0.32) mSv for male and (5.51 ±0.29) mSv for female patients from CT component. The total effective dose was (10.44 ±1.09) mSv for male and (11.60 ±0.79) mSv for female from ¹⁸F-FDG PET-CT examination, respectively. Whereas it was (8.30 ±0.50) mSv for male and (8.72 ±0.49) mSv for female from ¹⁸F-FET PET-CT examination, respectively. In the diagnostic-quality CT scan protocol, the effective dose was (16.28 ±1.01) mSv for male and (13.49 ±0.72) mSv for female patients from CT component. The total effective dose was (21.09 ±1.45) mSv for male and (19.58 ±1.03) mSv for female patients from ¹⁸F-FDG, respectively. Whereas it was (18.95 ±1.08) mSv for male and (16.70 ±0.81) mSv female patients from ¹⁸F-FET.Conclusion Different PET-CT scan parameters caused the patient to be exposed to different radiation doses. In the daily work, we should optimize the acquisitive parameters of PET and CT according to the actual situation of the examinee, and reduce the dose of examinee to practice the optimization of radiation protection.