214例新型冠状病毒肺炎疑似病例临床分析

目的 回顾分析214例新型冠状病毒肺炎(COVID-19)疑似病例的流行病学史、临床表现、CT影像学、血常规和核酸检测结果,为COVID-19防治提供参考资料。 方法 收集2020年1月24日—3月5日三亚市人民医院收治的214例新型冠状病毒肺炎疑似病例临床和实验室及新型冠状病毒（SARS-CoV-2）核酸检测结果资料,分析疑似病例在不同性别和年龄的分布情况。 结果 214例新型冠状病毒肺炎疑似病例中,SARS-CoV-2核酸检测阳性24例,SARS-CoV-2核酸阳性率为11.2%。不同性别和不同年龄段确诊感染率差异无统计学意义（P>0.05）。白细胞计数、淋巴细胞计数和C反应蛋白的变化在新型冠状病毒肺炎确诊病例和排除的疑似病例中差异无统计学意义（P>0.05）。24例确诊病例中,有明确的流行病学史23例（占95.8%）,呼吸道症状以发热和咳嗽为主。CT影像学表现为肺内可见不同程度的磨玻璃样密度影或双侧浸润等。 结论 新型冠状病毒肺炎疑似病例的确诊,在综合考虑其流行病学史和相应临床表现的基础上,仍需依靠病原学核酸检测。

Clinical analysis of 214 suspected cases of COVID-19

Objective A retrospective analysis of the epidemiological history, clinical manifestations, the results of CT, blood routine and nucleic acid test of 214 suspected cases with coronavirus disease 2019(COVID-19) in Sanya was conducted to provide a reference for the diagnosis of the disease. Methods The epidemiological data, clinical manifestations, and SARS-CoV-2 nucleic acid test of 214 suspected cases of COVID-19 from Sanya People's Hospital from January 24th to March 5th, 2020 were collected. The confirmed infection rates of 214 suspected patients of different genders and ages were analyzed. The white blood cell count, lymphocyte count, C-reactive protein, clinical manifestations and CT of 214 suspected patients were analyzed. Results Among the 214 suspected cases of COVID-19, 24(11.2%) were positive for viral nucleic acid. There were no significant differences in the rates of confirmed infections of different genders in 214 suspected cases of COVID-19 (P>0.05); there was no significant difference in the confirmed infection rates of different age groups ( P>0.05). The changes in white blood cell counts, lymphocyte counts, and C-reactive protein had no significant difference in the infection rate of COVID-19 (P>0.05 ). Of the 24 confirmed cases, 23 had a related epidemiological history (95.8%), and the respiratory symptoms were mainly fever and cough. CT images of 24 confirmed cases showed different degrees of ground glass-like density or bilateral infiltration in lungs. Conclusion The diagnosis of suspected cases of COVID-19, based on a comprehensive analysis of epidemiological history and corresponding clinical manifestations of patients, and it still needs to rely on pathogenic nucleic acid detection.