广东省江门地区非婚异性性传播艾滋病患者死亡情况的队列研究

目的 了解江门地区非婚非商和商业异性性传播艾滋病患者病死率危险性的关系。方法 使用χ²检验和单因素、多因素Cox分析不同性伴侣数的非婚非商和商业异性性传播艾滋病患者的死亡相对危险性。结果 非婚非商异性传播（P<0.05）和商业异性传播（P<0.05）在性伴侣数不同时病死率差异有统计学意义,单因素分析显示非婚非商的2级（RR=2.63,95%CI=2.52~2.71）、3级（RR=1.61,95%CI=1.42~1.73）和商业的2级（RR=2.11,95%CI=1.71~2.33）、4级（RR=1.52,95%CI=1.43-1.76）与其各自对应的1级相比死亡危险度更高,经调整性别、确诊年龄、样本来源、基线CD4水平、抗病毒治疗后不同性伴侣数级别与非婚非商业异性传播患者病死率相对危险度呈正相关（RR=1.12,P<0.05）。结论 本研究表明性伴侣数越多非婚非商业异性性传播艾滋病病死率越高。

A cohort study on death rate of heterosexual transmission of unmarried HIV/AIDS patients in Jiangmen,Guangdong

Objective To understand the relationship between heterosexual transmission of unmarried(included commercial and uncommercial) and rate of death on the HIV/AIDS patients in Jiangmen. Methods The relative risk of death was analysed between commercial and uncommercial heterosexual transmission of unmarried HIV/AIDS patients by Chi-square, single and multi Cox regression. Results It showed that there were significantly difference in the rate of death between different numbers of sex partners in uncommercial（P<0.05） and commercial（P<0.05） unmarried heterosexual transmission; univariate analyse showed that compared with each level 1 , level 2（RR=2.63,95%CI=2.52-2.71） and level 3（RR=1.61,95%CI=1.42-1.73） of unmarried and uncommercial heterosexual transmission, as well as level 2（RR=2.11,95%CI=1.71-2.33） and level 4（RR=1.52,95%CI=1.43-1.76） of unmarried and commercial heterosexual transmission were at higher risk. Only unmarried heterosexual transmission of uncommercial(RR=1.12, P<0.05), were positively correlated with rate of death in HIV/AIDS patients by adjusting confounders such as sex distinction, age of diagnoses, source of sample, baseline CD4 cell count, antiviral therapy. Conclusion This suggested that the more sex partners, the higher rate of death in the patients by uncommercial and unmarried heterosexual transmission.