血小板与淋巴细胞比值对肝硬化患者肾脏损伤病情的评估效果

目的 探索血小板与淋巴细胞比值对肝硬化患者肾脏损伤病情的评估效果。方法 回顾性分析2018年1月—2019年1月于保定市传染病医院接受治疗的196例肝硬化患者的临床资料,114例单纯肝硬化患者为对照组,82例肝硬化合并肾脏损伤患者为观察组。收集两组患者临床资料及实验室指标进行对比,对具有统计学意义的可能影响肝硬化患者肾脏损伤的相关因素进行多因素logistic回归分析,计算ESR、NLR、PLR指标对评估肝硬化患者肾脏损伤病情的灵敏度、准确度及特异度。结果 两组患者BMI差异无统计学意义（P>0.05）;观察组收缩压、ESR、NLR、PLR、hs-CRP、IL-6、BUN、Scr指标水平高于对照组（P<0.05）。多因素Logistic回归分析结果显示,ESR、NLR、PLR、IL-6、BUN、Scr指标是影响肝硬化患者并发肾脏损伤的相关因素（P<0.05）。本次研究共82例肝硬化并发肾脏损伤患者,ESR、NLR、PLR三项指标单独检测中ESR特异度最高,NLR灵敏度最高,PLR准确度最高;联合检测灵敏度、准确度、特异度均分别高于单独检测。结论 ESR、NLR、PLR能够反映肝硬化患者肾脏损伤的发生风险,联合检测对肝硬化患者肾脏损伤病情的评估效果较好,临床医师治疗时可以根据患者ESR、NLR、PLR水平对患者病情进行初步判断。

Evaluation effect of platelet to lymphocyte ratio on renal injury in patients with liver cirrhosis

Objective To explore the effect of platelet-to-lymphocyte ratio on the assessment of renal injury in patients with cirrhosis. Methods A clinical data of 196 patients with cirrhosis who were treated in Baoding Infectious Diseases Hospital from January 2018 to January 2019 were retrospectively analyzed, 114 patients with simple cirrhosis were in the control group, and 82 patients with cirrhosis and renal injury were included in the observation group. The clinical data and laboratory parameters of the two groups were collected for comparison. The multivariate logistic regression analysis was performed on the statistically significant factors affecting renal damage in patients with cirrhosis. Sensitivity, accuracy and specificity of ESR, NLR and PLR indicators were calculated to evaluate the renal injury in patients with liver cirrhosis. Results There was no statistically significant difference in BMI between the two groups (P>0.05). The systolic blood pressure, ESR, NLR, PLR, hs-CRP, IL-6, BUN, and Scr levels in the observation group were significantly higher than those in the control group (P<0.05). Multivariate logistic regression analysis showed that ESR, NLR, PLR, IL-6, BUN, and Scr were independent risk factors for renal injury in patients with cirrhosis (P<0.05). In this study, a total of 82 patients with cirrhosis complicated with renal injury, in the separate detection of ESR, NLR, PLR three indicators, ESR index specificity, NLR index sensitivity, PLR index accuracy were the highest; sensitivity, accuracy, specificity of joint detection were higher than the individual detection. Conclusion ESR, NLR, and PLR can reflect the risk of renal injury in patients with cirrhosis. The combined detection of renal damage in patients with cirrhosis is effective. The clinician can preliminarily determine the patient's condition according to the ESR, NLR, and PLR levels.