西洋参抗疲劳作用及对迟发型超敏反应单核吞噬细胞功能影响的实验研究

目的:观察西洋参抗疲劳作用,对迟发型超敏反应强度、单核吞噬细胞功能的影响。方法:通过游泳法,观察西洋参对氢化可的松所致阴虚小鼠的游泳生存时间的影响;采用溶血空斑法,观察西洋参对豚鼠迟发型超敏反应强度的影响;采用小鼠碳粒廓清法,观察西洋参对小鼠单核细胞吞噬指数的影响。结果:西洋参能显著延长阴虚小鼠的游泳时间,与模型对照组比较,高、低剂量组均有显著性差异(P<0.01,P<0.05);可显著提高豚鼠迟发型超敏反应的强度,空斑实验比色OD值与模型对照组比较,高、低剂量组均有显著性差异(P<0.01);可提高小鼠单核细胞的吞噬指数,高、低剂量组与模型对照组比较,有显著性差异(P<0.05)。结论:西洋参可显著提高氢化可的松所致阴虚小鼠免疫能力;提高迟发型超敏反应的强度和小鼠单核吞噬细胞的能力。说明该药具有提高机体免疫力,扶正固本的作用。

Empirical Study of American Ginseng on Anti- defatigation Action and the Effects of Delayed Hypersensitivity and the Function of Mononuclear Phagocyte

Objective:To observe the action of American ginseng on anti-defatigation,and the effects on delayed hypersensitivity intensity and the function of mononuclear phagocyte.Methods:By swimming method to observe the effect of American ginseng on swimming live time of yin-deficiency Jimpy mice caused by Hydrocortisone;Adopting haemolysis lacuna method to observe the effect of American ginseng on delayed hypersensitivity intensity of cavia cobaya;using carbon particle clearance method to observe the effect of American ginseng on monocyte cytophagic index of Jimpy mice.Results:American ginseng can significantly prolongation the swimming time of yin-deficiency Jimpy mice,compared with modle control group,the high-dose group and the low-dose group have the significant difference(P<0.01,P<0.05);It can significantly increase the delayed hypersensitivity intensity of cavia cobaya,compared with modle control group,the high-dose group and the low-dose group have the significant difference(P<0.01)in lacuna experiment shade selection OD numerus;It can increase the monocyte cytophagic index of Jimpy mice,compared with modle control group,the high-dose group and the low-dose group have the significant difference(P<0.05).Conclusions:American ginseng can significantly increase immune competence of yin-deficiency Jimpy mice caused by Hydrocortisone;increase the delayed hypersensitivity intensity and the capability of mononuclear phagocyte.These indicate that this herb has the effects of increasing organism immunity and supporting healthy energy.