清心冲剂Ⅰ号联合利培酮、奥氮平治疗精神分裂症的临床对照研究

目的观察清心冲剂Ⅰ号对于利培酮、奥氮平治疗精神分裂症有无增效作用。方法将清心冲剂Ⅰ号合并利培酮、奥氮平治疗者作为实验1组，不合并清心冲剂Ⅰ号的作为对照1组；清心冲剂Ⅰ号加氯丙嗪、氟哌啶醇、奋力静治疗者为实验2组，不合并清心冲剂Ⅰ号的作为对照2组，观察疗程8周。在治疗前及治疗后2、4、8周采用PANSS量表评价疗效。结果治疗前及治疗后实验组与对照组总体疗效比较差异无显著性（P〉0．05）；实验组与对照组治疗8周末PANSS和各症状评分较治疗前差异均有显著性（P〈0．01），8周后实验组与对照组阳性症状分比较差异有显著性（P〈0．05）。结论清心冲剂Ⅰ号对于抗精神病药物治疗精神分裂症有增效作用，尤其可以改善精神分裂症患者的阳性症状，因此在精神分裂症的治疗中有一定的临床价值。

A Study of Qing Xin Ⅰ Combinaed with Risperidone or Olanzapine in the Treatment of Schizophrenia.

Objective To evaluate the add-on therapeutic effect of the self-dispense herb formula-Qing Xin Chong Ji-I combined with risperidone and olanzapine in the treatment of schizophrenia.Methods All the subjects were diagnosed as schizophrenia according to the CCMD-3 diagnosis standard and were randomized into 4 groups:the treatment group 1(Qing Xin Chong Ji-I combined with risperidone or olanzapine)and the control group 1 without Qing Xin Chong Ji-I;the treatment group 2(Qing Xin Chong Ji-I combined with chlorpromazine,haloperidol or perphenazine)and the control group 2 without Qing Xin Chong Ji-I;The treatment lasted for 8 weeks.The Positive and Negative Syndrome Scale(PANSS)were used to evaluate therapeutic effects.Results There were no significantly difference of the total efficacy between the treatment groups and the control groups after 8 weeks of treatment(P>0.05).The total scores,the scores of positive syndrome,negative syndrome and general syndrome of PANSS in the treatment group and the control groups were significantly different before and after 8 weeks(P<0.01).Conclusion Qing Xin Chong Ji-I has add-on effect for risperidone and olanzapine in the treatment of schizophrenia,especially effective for the positive symptoms of schizophrenia.It can has clinical value in the treatment of schizophrenia.