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| Factors that impact health-related quality of life in adults with celiac disease： A multicenter study | |
| 引用本文： | Casellas F,Rodrigo L,Vivancos JL,Riestra S,Pantiga C,Baudet JS,Junquera F,Diví VP,Abadia C,Papo M,Gelabert J,Malagelada JR.Factors that impact health-related quality of life in adults with celiac disease： A multicenter study[J].世界胃肠病学杂志(英文版),2008,14(1):46-52. |
| 作者姓名： | Casellas F Rodrigo L Vivancos JL Riestra S Pantiga C Baudet JS Junquera F Diví VP Abadia C Papo M Gelabert J Malagelada JR |
| 作者单位： | [1]Digestive System Research Unit,Hospital Universitari Vail d＇ Hebron, Barcelona, Spain [2]Digestive System Research Unit, Hospital Central de Asturias, Oviedo, Spain [3]Digestive System Research Unit, Internal Medicine Department, Hospital General de Catalunya, Barcelona,Spain [4]Digestive System Research Unit, Hospital Virgen dela Candelaria, Santa Cruz de Tenefife, Spain [5]Digestive System Research Unit,Corporacio Parc Tauli, Sabadell, Spain [6]Digestive System Research Unit, Hospital Joan X X Ⅲ, Tarragona, Spain [7]Digestive System Research Unit, Hospital Verge delToro, Menorea, Spain |
| 摘 要： | AIM： TO evaluate the factors involved in the impairment of health-related quality of life （HRQOL） in patients with celiac disease. METHODS： A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires： the gastrointestinal quality of life index （GIQLI） and the EuroQol-5D （EQ）. RESULTS： Three hundred and forty patients （163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet） were included. The GIQLI score was significantly better in patients on a gluten- free diet （GFD） than in non-treated patients on their usual diet, both in terms of the overall score （3.3 vs 2.7, respectively; P 〈 0.001）, as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients （0.93 vs 0.72 P 〈 0.001 and 80 vs 70 P 〈 0.001, respectively）. Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status. CONCLUSION： In untreated celiac disease, the most important factors that influence patient perception ofhealth are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. |
| 关 键 词： | 乳糜泻 成年人 慢性营养不良 健康情况 生存质量 |
| 收稿时间： | 2007 Aug 24 |
Factors that impact health-related quality of life in adults with celiac disease: a multicenter study |
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| Casellas F,Rodrigo L,Vivancos J López,Riestra S,Pantiga C,Baudet J S,Junquera F,Diví V Puig,Abadia C,Papo M,Gelabert J,Malagelada J R.Factors that impact health-related quality of life in adults with celiac disease: a multicenter study[J].World Journal of Gastroenterology,2008,14(1):46-52. | |
| Authors: | Casellas F Rodrigo L Vivancos J López Riestra S Pantiga C Baudet J S Junquera F Diví V Puig Abadia C Papo M Gelabert J Malagelada J R |
| Institution: | 1. Digestive System Research Unit,Hospital Universitari Vail d' Hebron,Barcelona,Spain 2. Digestive System Research Unit,Hospital Central de Asturias,Oviedo,Spain 3. Digestive System Research Unit,Internal Medicine Department,Hospital General de Catalunya,Barcelona,Spain 4. Digestive System Research Unit,Hospital Virgen de la Candelaria,Santa Cruz de Tenerife,Spain 5. Digestive System Research Unit,Corporaci(o) Pare Tauli,Sabadcll,Spain 6. Digestive System Research Unit,Hospital Joan X X ffl,Tarragona,Spain 7. Digestive System Research Unit,Hospital Verge del Toro,Menorca,Spain |
| Abstract: | AIM:To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-SD (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten- free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7,respectively; P<0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P<0.001 and 80 vs 70 P<0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD,and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet.HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. |
| Keywords: | Celiac disease Health status Quality of life Gluten-free diet celiac disease adults quality of life impact Factors levels similar general population influence patient perception health presence symptoms symptomatic status failure Variables associated |
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