| 增龄对大鼠血清卵磷脂胆固醇酰基转移酶活性的影响 |
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| 引用本文： | 谈运良,姚培发,王洪复.增龄对大鼠血清卵磷脂胆固醇酰基转移酶活性的影响[J].中国老年学杂志,1993(2). |
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| 作者姓名： | 谈运良 姚培发 王洪复 |
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| 作者单位： | 湖北省老年医学研究所，上海中医学院，上海医科大学老年医学研究中心 武汉 430071 |
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| 摘 要： | 本文采用比色法对不同月龄大鼠血清卵磷脂胆固醇酰基转移酶(LCAT)活性进行了测定。结果表明,20月龄组LCAT活性明显低于4月龄组(P<0.05),表明血清LCAT活性在老年时降低。LCAT活性下降可导致胆固醇酯化和HDL_3向HDL_2转化障碍,影响胆固醇的逆向转运,促进动脉粥样硬化的形成。
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| 关 键 词： | 卵磷脂胆固醇酰基转移酶 脂蛋白代谢 衰老 大鼠 |
Effect of Ageing on the Serum LCAT Activity in Rats |
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| Tan Yunliang et al Hubei Provincial Institute of Ceriatric Medicine,Wu han.Effect of Ageing on the Serum LCAT Activity in Rats[J].Chinese Journal of Gerontology,1993(2). |
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| Authors: | Tan Yunliang Hubei Provincial Institute of Ceriatric Medicine Wu han |
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| Institution: | Tan Yunliang et al Hubei Provincial Institute of Ceriatric Medicine,Wu han 430071 |
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| Abstract: | The activities of the serum lecithin cholesterol acyl transferase (LCAT) in 4-month and 20-month rats wearmeasured by colorimetric method. The results showed that the LCAT activity in 20-month rats was importantlylower than that in 4-month rats. The lower LCAT activities lead to disorder of esterification of cholesterol andtransformation from HDL_3 to HDL_2 and retrograde transfer of choleterol and promote the formation ofatherosclerosis. |
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| Keywords: | LCAT lipoprotein Metaboism Ageing Rat |
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