| Graves病与HLA－DR、DQ抗原关联的研究 |
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| 引用本文： | 杨立勇,林经安,王中心.Graves病与HLA－DR、DQ抗原关联的研究[J].福建医科大学学报,1996(1). |
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| 作者姓名： | 杨立勇 林经安 王中心 |
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| 作者单位： | 福建医学院附属第一医院内二科，福建医学院附属第一医院检验科 |
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| 摘 要： | 目的：探讨ＨＬＡ－ＤＲ、ＤＱ抗原与Ｇｒａｖｅｓ病发病的关系。方法：检测５０例Ｇｒａｖｅｓ病患者１４种ＨＬＡ－ＤＲ、ＤＱ抗原，并与５０例健康献血员对照，结果：Ｇｒａｖｅｓ病患者ＨＬＡ－ＤＲ１抗原频率和相对危险度明显高于对照组。结论：ＨＬＡ－ＤＲ１抗原与Ｇｒａｖｅｓ病呈强关联，Ｇｒａｖｅｓ病的发病有一定的遗传基础。
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| 关 键 词： | Graves病，HLA－DR抗原，HLA－DQ抗原 |
Relationship between Graves'Disease and HLA-DR,DQ Antigens |
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| Yang Liyong,Lin Jing''''an,Wang Zhongxin.Relationship between Graves''''Disease and HLA-DR,DQ Antigens[J].Journal of Fujian Medical University,1996(1). |
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| Authors: | Yang Liyong Lin Jing'an Wang Zhongxin |
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| Abstract: | Objective:In this study l4 HLA-DR,DQ antigens were determined in 50 patients with Graves,disease(GD),and 50 healthy donors served as controls,Results:A marked increase in the frequency and relative risk(RR)of HLA-DR1 antigen was observed in the patients compared with the controls.Conclusion:There is a close association between HLA-DR1 antigen and GD,revealing an inheritance foundation in the pathogenesis of GD. |
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| Keywords: | Graves'disease HLA-DR antigen HLA-DQ antigen |
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