米非司酮米索前列醇联合清宫术治疗稽留流产效果研究

目的：评价米非司酮、米索前列醇联合清宫术治疗稽留流产（MA）的临床效果。方法选取2013年7月—2016年7月在我院接受治疗的MA患者60例，随机分为对照组和观察组，每组30例，其中对照组口服戊酸雌二醇片3 d后行清宫术治疗，观察组予以米非司酮配伍米索前列醇+清宫术治疗。比较2组的治疗效果。结果观察组住院时间、阴道出血量、疼痛及人工流产综合征（RASS）发生率均显著少于对照组（P<0.05），而一次性清宫成功率和宫颈扩张总有效率均明显高于对照组（P<0.05）。结论与传统雌激素+清宫术相比，米非司酮、米索前列醇联合清宫术在提高MA治疗效果、减少并发症方面更具优势。

Study on the effect of Mifepristone and Misoprostol combined with uterine curettage in the treatment of missed abortion

Objective To evaluate the effect of mifepristone and misoprostol combined with uterine curettage on MA. Methods 60 patients with MA in our hospital from July 2013 to July 2016, were randomly divided into control group and observation group, 30 cases in each group. The control group treated with Estrace+uterine curettage, and the observation group was given mifepristone+misoprostol+uterine curettage. The treatment effect of the two groups was compared. Results Length of stay, vaginal bleeding, pain and the incidence of RASS of the observation group were significantly lower than those of the control group (P<0.05), and one-time success rate and the total effective rate of cervical dilatation were significantly higher than those of the control group (P<0.05). Conclusion Compared with traditional estrogen+uterine curettage, mifepristone and misoprostol combined with uterine curettage has more advantages in improving the therapeutic effect of MA and reduce the complications.