Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550 |
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| Authors: | Ui Hideaki Shiomi Kazuro Suzuki Hideaki Hatano Hiroko Morimoto Hiromi Yamaguchi Yuichi Masuma Rokuro Sakamoto Kimitoshi Kita Kiyoshi Miyoshi Hideto Tomoda Hiroshi Tanaka Haruo Omura Satoshi |
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| Affiliation: | Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan. |
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| Abstract: | A new NADH-fumarate reductase inhibitor, paecilaminol, was isolated from the cultured broth of a fungus Paecilomyces sp. FKI-0550. It is an amino alcohol compound, the structure being established as 2-amino-14,16-dimethyl-3-octadecanol. Paecilaminol exhibited an IC50 value of 5.1 microM against Ascaris suum NADH-fumarate reductase. |
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