| 血塞通对兔下肢缺血再灌注自由基信号的影响 |
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| 引用本文： | 刘继前,安荣姝,尚宪荣,曹建春,曹刚,陈朝晖.血塞通对兔下肢缺血再灌注自由基信号的影响[J].中华中医药杂志,2008,23(1):62-64. |
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| 作者姓名： | 刘继前 安荣姝 尚宪荣 曹建春 曹刚 陈朝晖 |
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| 作者单位： | 1. 北京中医药大学东方医院,北京,100078
2. 中日友好医院,北京,100029 |
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| 摘 要： | 目的:探讨血塞通对下肢缺血再灌注损伤的保护作用。方法:采用电子自旋共振技术和电子自旋共振捕集技术(N-tert-butyl-2-phenylnitrone,PBN)观察兔下肢缺血再灌注时出现PBN-自旋加合物信号。结果:该信号强度与缺血时间有关,缺血4h再灌注时的信号明显强于缺血2h再灌注;血塞通对该自旋加合物信号有明显猝熄作用。结论:血塞通对下肢缺血再灌注损伤具有一定的保护作用。
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| 关 键 词： | 三七总皂苷(血塞通) 游离基类 电子自旋共振 实验研究 |
| 收稿时间： | 2007-05-16 |
| 修稿时间： | 2007年5月16日 |
Effect of Xuesaitong on lower limb of rabbit ischemia-reperfusion free radical |
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| LIU Ji-qian,AN Rong-shu,SHANG Xian-rong,CAO Jian-chun,CAO Gang,CHEN Zhao-hui.Effect of Xuesaitong on lower limb of rabbit ischemia-reperfusion free radical[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(1):62-64. |
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| Authors: | LIU Ji-qian AN Rong-shu SHANG Xian-rong CAO Jian-chun CAO Gang CHEN Zhao-hui |
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| Abstract: | Objective: To investigate the protective effect of Xuesaitong(total saponins of sanchi) on lower extremity ischemical reperfusion injury.Methods: To observe PBN-spin bulky adducts signal of lower extremity ischemical reperfusion of rabbit by using electron spin resonance technology and electron spin resonance promoter N-tert-butyl-2-phenylnitrone(PBN).Results: The signal intensity is correlated with time,compared with ischemia for 2 hours,the signal intensity of ischemia for 4 hours increased apparently.Xuesaitong would quench PBN-spin bulky adducts signal significantly.Conclusion: Xuesaitong have protective effect on lower extremity ischemia-reperfusion injury. |
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| Keywords: | Total saponins of sanchi(Xuesaitong) Free radical Electron spin resonance Experimental study |
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