| 电刺激糖尿病大鼠血管舒张神经反应性变化的研究 |
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| 引用本文： | 蔡际群,王秋月,金松华,关福兰,金万宝. 电刺激糖尿病大鼠血管舒张神经反应性变化的研究[J]. 中国危重病急救医学, 2002, 14(12): 736-738 |
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| 作者姓名： | 蔡际群 王秋月 金松华 关福兰 金万宝 |
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| 作者单位： | 1. 中国医科大学基础医学院药理教研室,辽宁,沈阳,110001
2. 第一临床学院内分泌科 |
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| 基金项目： | 国家自然科学基金资助项目 (No.A39970 349) |
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| 摘 要： | 目的 :研究不同病期的糖尿病大鼠外周血管舒张神经是否发生病变。方法 :将不同病期链佐霉素(STZ)性糖尿病及对照组大鼠制成毁脑脊髓大鼠模型 ,在用六烃季胺阻断内源性去甲肾上腺素释放及在甲氧明升压基础上 ,对比观察了脊髓内电刺激诱发的外周血管舒张效应。结果 :4周和 8周糖尿病大鼠脊髓内电刺激诱发的血管舒张反应未见明显改变 ,而 12周糖尿病大鼠反应性明显降低。结论 :随着糖尿病病程的延长及病情的进展 ,外周血管舒张神经可能发生病变而导致其功能降低。
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| 关 键 词： | 毁脑脊髓大鼠 链佐霉素 糖尿病 血管舒张神经 |
| 文章编号： | 1003-0603(2002)12-0736-03 |
| 修稿时间： | 2002-06-19 |
Study of functional changing of the peripherial vasodilator nerve of diabetic rats caused by electric stimulation |
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| CAI Jiqun ,WANG Qiuyue ,JIN Songhua ,GUAN Fulan ,JIN Wanbao .. Study of functional changing of the peripherial vasodilator nerve of diabetic rats caused by electric stimulation[J]. Chinese critical care medicine, 2002, 14(12): 736-738 |
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| Authors: | CAI Jiqun WANG Qiuyue JIN Songhua GUAN Fulan JIN Wanbao . |
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| Affiliation: | CAI Jiqun 1,WANG Qiuyue 2,JIN Songhua 1,GUAN Fulan 1,JIN Wanbao 1.1.Department of Pharmacology,China Medical University,Shenyang 110001,China,2.Department of Endocrinology,First Affiliated Hospital,China Medical University,Shenyang 110001,Liaoning,China |
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| Abstract: | Objective:To study the functional changes of the peripherial vasodilator nerve of diabetic rats in different disease period.Methods:The diabetic rats were prepared by streptozotocin (STZ) 60 mg/kg intraperitoneally. After pithing and infusing methoxamedrine and hexamethonium the vasodilator response induced by electrical stimulation with electrode in the spinal cord was detected.The vasodilator response in different disease period of STZ diabetic rats was compared with the control.Results:The vasodilator response did not show significant changes in 4week and 8week diabetic rats,but the vasodilator response showed significant decrease in 12week diabetic rats compared with control group.Conclusions:With prolonged diabetic status,the vasodilator nerve may produce a pathological change and a reduction in the function. |
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| Keywords: | pithed rat streptozotocin diabetes vasodilator nerve |
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