卵巢上皮性癌PTEN和PCNA的表达

目的: 探讨卵巢上皮性癌中PTEN和PCNA蛋白的表达及相关性. 方法: 采用免疫组织化学SABC法检测了128例卵巢上皮性癌,46例卵巢良性肿瘤和20例正常卵巢组织中PTEN和PCNA的蛋白表达,分析不同组织中PTEN及PCNA表达的差异及二者的相关性. 结果: 卵巢上皮性恶性肿瘤中PTEN蛋白表达水平明显低于卵巢良性肿瘤及正常卵巢组织,而PCNA蛋白表达水平与PTEN相反,随正常卵巢组织、良性卵巢肿瘤和卵巢恶性上皮性肿瘤顺序依次增髙,两者表现出明显的负相关(r=-0.511, P=0.000),且PTEN和PCNA蛋白表达与病理分化程度及临床分期有关(P<0.05). 结论: PTEN蛋白的表达下降与卵巢癌的发生、发展相关,而PCNA蛋白的表达增强则与卵巢癌组织的增殖及恶性程度有关.

Expression and significance of PTEN and PCNA in ovarian epithelial carcinoma

AIM: To investigate the expression of PTEN and PCNA in ovarian epithelial carcinoma and their relationship with clinicopathology.METHODS: The expression of PTEN and PCNA in 128 cases of ovarian epithelial carcinoma,46 cases of benign tumors and 20 cases of normal(ovarian) tissue were determined and compared by SABC immunohistochemical method.RESULTS: The positive rate of PTEN in ovarian carcinoma tissues was lower than that in benign tumor tissues and normal ovarian tissues and the expression trend of PCNA was opposite to that of PTEN((P<)0.05).In ovarian carcinoma,a negative correlation between expression PTEN and PCNA was observed((r=)(-0.511),P=0.000).The expression of PTEN and PCNA was relative to the pathological stages and clinical stages.CONCLUSION: The down-regulation of PTEN expression in(ovarian) carcinoma is associated with the genesis and development of ovarian carcinoma and the up-regulation of PCNA expression is associated with the proliferation and pathological differentiation of the tumor tissues.