| Affiliation: | 1. Department of Obstetrics and Gynecology, Hyogo Prefectural Kaibara Hospital, Tanba, Japan;2. Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan;3. Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi, Japan;4. Department of Diagnostic Pathology, Kumamoto University, Kumamoto, Japan;5. Department of Diagnostic Pathology, Hyogo Prefectural Kaibara Hospital, Tanba, Japan |
| Abstract: | BackgroundThe presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma is extremely rare.CaseA 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but developed severe respiratory failure and died after 9 months. Autopsy showed that the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass, and the cardiac wall had a massive invasive lesion. Histopathological examination of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component with infiltrating osteoclastic giant cells.ConclusionThis case is very rare, and the clinical management of anaplastic carcinoma arising in mucinous neoplasms remains challenging. |
