Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione |
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| Authors: | Yuriy M. Kononevich Ludmila S. Bobkova Alexander S. Smolski Anatoly M. Demchenko |
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| Affiliation: | 1A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova str. 28, 119991, Moscow, Russian Federation;2Institute of Pharmacology and Toxicology, National Academy of Medical Science of Ukraine, Ezhena Pot’je str. 14, 03680, Kyiv, Ukraine;3T. G. Shevchenko Chernihiv National Pedagogical University, Het’mana Polubotka str. 53, 14013, Chernihiv, Ukraine |
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| Abstract: | New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe2+-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule. |
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| Keywords: | 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione Alkylation Antioxidant activity Fe2+-dependent oxidation of adrenaline |
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