血栓前体蛋白和糖原磷酸化酶同工酶BB对急性心肌梗死早期诊断的价值

目的 评价血栓前体蛋白(TpP)和糖原磷酸化酶同工酶BB(GPBB)对急性心肌梗死(AMI)早期诊断的潜在价值。方法 选择168例确诊或疑似AMI的患者，以酶联免疫吸附法(ELISA)测定干预前其血浆TpP和GPBB浓度，同期常规检测肌酸激酶同工酶：MB(CK-MB)、门冬氨酸氨基转移酶(AST)牙和心脏肌钙蛋白I(CTnI)，比较这些生化指标对AMI的诊断价值。结果 这五种生化标志物中，TpP和GPBB诊断AMI优势明显，两者灵敏度分别为100％和96．5％：特异度分别为85．5％和90．9％；真实度分别为95．2％和94．1％；阳性预测值分别为93．4％和95．6％；阴性预测值分别为100％和192．6％。结论 血浆TpP和GPBB是有价值的早期诊断AMI的生化指标。

Value of thrombus precursor protein and glycogen phosphorylase-BB isoenzyme for early diagnosis of acute myocardial infarction

Objectives To evaluate the potential value of thrombus precursor protein (TpP) and glycogen phosphorylase BB isoenzyme(GPBB) for early diagnosis of acute myocardial infarction (AMI). Methods One hundred and sixty eight patients suggestive of AMI were enrolled. The plasma TpP and GPBB were detected by enzyme linked immunosorbent assay (ELISA) before intervention, meanwhile the plasma crcatinc kinase MB isoenzyme (CK MB), aspartatc aminotransferase (AST) and cardiac troponin I (CTnI) were also measured conventionally, and then the diagnostic values of these biochemical makers for AMI were compared. Results Among these biochemical markers, TpP and GPBB had an advantage in early diagnosis of AMI. The sensitivity was 100% and 96 5%; specificity 85 5% and 90 9%; certainty 95 2% and 94 1%; positive predictive value 93 4% and 95 6%; negative predictive value 100% and 92 6% respectively.Conclusions Plasma TpP and GPBB are valuable biochemical markers for early diagnosis of AMI.