血清低密度脂蛋白、C-反应蛋白、纤维蛋白原在评估冠状动脉狭窄程度及临床稳定性中的作用

目的:探讨冠状动脉粥样硬化危险因子低密度脂蛋白(LDL)、纤维蛋白原(FIB)、C-反应蛋白(CRP)在冠状动脉狭窄程度和斑块稳定性评估中的作用。方法:选择2008年9月至2009年3月我院心内科住院拟诊断冠心病的患者249例,统计入院12h内行血脂、CRP、FIB检测资料,及冠状动脉造影检查结果。1.依据Gensini法评分分组,分析血脂、CRP、FIB与冠状动脉狭窄程度的关系;2.按临床诊断分组,分析LDL、CRP、FIB浓度与斑块稳定性间的关系。结果:1.年龄、LDL、FIB在Gensini评分不同分段间差异有统计学意义(P0.05),C反应蛋白组间差异无统计学意义(P=0.62)。年龄、LDL、FIB与Gensini评分呈正相关(OR=0.169,P=0.007;OR=0.231,P=0.001;OR=0.149,P=0.041),CRP与Gensini评分不相关(OR=0.112,P=0.104);2.患者血清CRP,FIB在不同临床诊断组间差异有统计学意义(P0.05),LDL组间差异无统计学意义(P=0.08)。结论:高龄、LDL、FIB浓度增高与冠状动脉狭窄程度加重相一致,炎症因子CRP浓度对冠状动脉狭窄程度影响不显著但对斑块稳定性影响明确;血清FIB浓度增高对斑块不稳定性具有明确的预测作用。

The predictive value of serum LDL CRP FIB for the stenosis of coronary and the stability of atherosclerotic plaque

Objective:To evaluate the emphasis of serum C-reactive protein(CRP),fibrinogen(FIB) and Low density lipoprotein(LDL) that used to predict the stenosis of coronary and the stability of atherosclerotic plaque most often,so that we used it more accurate to predict them.Methods:Two hundred and forty nine patients(179men,70women;mean age 60.16),whose primary diagnosis is coronary heart disease without other organic heart disease,underwent coronary angiography were chosen.The data of LDL,CRP,FIB which detected du...