F／T—PSA比值在T—PSA小于10ng／ml时的意义

为研究F／T－PSA比值在PSA 0-10ng/ml时特异性和敏感性，随机选择住院和门诊明确诊断为BPH的病例253例，作肛门指检、经直肠超声检查及血清T－PSA和F－PSA检测。血清T－PSA和F－PSA检测采用单克隆抗体包被管放射免疫分析法。结果：1．随着血清T－PSA的上升，F／T－PSA比值呈现下降，T－PSA值与F／T－PSA比值呈负相关性。2．T－PSA和F－PSA与年龄增长呈正相关（P＜0．01），F／T－PSA比值与年龄差无相关性。作者认为T－PSA值在正常范围，F／T－PSA比值提高T－PSA的敏感性；T－PSA值增高，F／T－PSA比值提高T－PSA的特异性。这些有助于诊断早期前列腺癌。

The value of free-to-total PSA rotio at PSA level less than 10 ng/ml

In order to study the sensitivity and specificity of free to total PSA ratio,when PSA ranging from 0 to 10 ng/ml,a total of 253 men with BPH were randomly chosen and underwent a detailed clinical examination that included digital rectal examination and serum PSA determination using monoclonal antibody sandwich radioimmunoassay.Results:(1)along with ascension of serum T?PSA,the ration of free to total PSA appear to decline.T?PSA and the free to total PSA ratio display negative interrelationship.(2)T?PSA and F?PSA correlated directly with patients age ( P <0.001) and there was no relation between free to total PSA ratio and patient's age when PSA is 0 to 5 ng/ml.The results showed that if the total PSA value is normal,the F/T?PSA ratio improves the sensitivity of the PSA test;if the total PSA value is slightly elevated,the F/T?PSA ratio enhances the specificity of the PSA test.This result may be helpful to diagnostic is of early prostatic carcinoma.