Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women |
| |
| Authors: | Manco Melania Fernandez-Real J Manuel Equitani Francesco Vendrell Joan Valera Mora Maria Elena Nanni Giuseppe Tondolo Vincenzo Calvani Menotti Ricart Wilfredo Castagneto Marco Mingrone Geltrude |
| |
| Institution: | Department of Internal Medicine, Catholic University, Rome, Italy. melaniamanco@tiscali.it |
| |
| Abstract: | CONTEXT: Obesity may be regarded as a low-grade inflammatory state. OBJECTIVE: The aim of this study was to evaluate changes in pro-inflammatory adipocytokines and the innate immune system, cardiovascular risk, and insulin sensitivity after massive weight loss. DESIGN: This was a longitudinal study. Setting: The study was conducted at Catholic University, Rome. SUBJECTS AND METHODS: There were 10 normoglucose-tolerant obese women evaluated before and 36 months after bilio-pancreatic diversion (BPD). Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/permeability increasing protein (BPI), alpha-defensins, soluble CD14 receptor (sCD14), C-reactive protein, adiponectin, leptin, visfatin, IL-6, and TNF-alpha were assayed. RESULTS: After massive weight loss (53% of excess body weight), leptin (P
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
