The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis |
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Authors: | Cuneyt Ozden Ozdem Levent Ozdal Ozer Guzel Ozge Han Selda Seckin Ali Memis |
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Institution: | (1) Department of Urology, Numune Education and Research Hospital, Cevizlidere Mah. 14. Cad., Balgat 12/25, Ankara, 06100, Turkey;(2) Department of Pathology, Numune Education and Research Hospital, Ankara, Turkey |
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Abstract: | Introduction Asymptomatic inflammatory prostatitis is a common pathological finding in patients with benign prostatic hyperplasia (BPH).
In the present study, we evaluated the correlation between serum prostate specific antigen (PSA) level and extent and aggressiveness
of inflammation in surgical specimens of patients who underwent to surgery for BPH without any evidence of clinical prostatitis.
Methods Histological sections of the prostatic tissues of 52 patients were scored for the extent of inflammation and aggressiveness
of inflammation, using the four point scale designed by Irani et al. Extent of inflammation is graded from 0 to 3 according
to the degree of invasion of inflammatory cells in prostate tissue. Aggressiveness of inflammation is graded from 0 to 3 according
to the degree of contact or disruption of prostatic glandular epithelium by inflammatory cells. The serum PSA levels in different
inflammation grades were compared.
Results There was a significant correlation between inflammation and aggressiveness scores (r = 0.39, P < 0.01). Median PSA levels in grades 1, 2 and 3 extent of inflammation were 2.4, 5.2 and 5.7 ng/ml, respectively. There was
not any significant difference between these grades for PSA. Furthermore, median PSA levels in grades 1, 2 and 3 aggressiveness
of inflammation were 4.4, 4.8 and 8.7 ng/ml, respectively. There was a significant difference between grades of aggressiveness
of inflammation and PSA levels.
Conclusion High serum PSA levels may correlate with asymptomatic inflammatory prostatitis with high aggressiveness score in BPH patients
without clinical prostatitis. |
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Keywords: | Benign prostatic hyperplasia Prostate specific antigen Prostatitis Asymptomatic inflammation Prostatectomy |
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