皮肤屏障功能研究进展

皮肤屏障主要由角化包膜和脂质膜、中间丝聚合蛋白、角蛋白、角化桥粒、板层小体和角质层角质形成细胞问质、紧密连接等组成,防止水分的丢失及阻止外界的侵害,维持机体内稳态.基因突变、变应原、微生物、紫外线等因素共同作用下,能导致皮肤屏障结构、代谢及功能的异常,引起鱼鳞病、特应性皮炎等皮肤病.阐明皮肤病与屏障结构及功能异常联系,指导开发有效的诊疗和预防措施.

Advances in skin barrier function

The skin barrier, primarily comprised of cornified envelope, corneocyte lipid envelope, filaggrin, keratin, corneodesmosome, lamellar body, intercellular lipid matrix, and tight junction, maintains the homeostasis of internal systems by restricting transepidermal water loss and protecting the body from hostile environment. Genetic mutations, allergens, pathogenic microbes, and ultraviolet irradiations, may affect the structure, metabolism, and function of the skin barrier, result in dermatoses such as ichthyosis and atopic dermatitis. Further elucidation of the relationship of abnormalities in skin barrier structure and function to dermatoses would be beneficial to the development of more appropriate and effective assessment, management, and prevention strategies.