Role of Heart Rate as a Marker and Mediator of Poor Outcome for Patients with Heart Failure |
| |
Authors: | John R Kapoor Paul A Heidenreich |
| |
Institution: | University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, Chicago, IL, 60031, USA. doctorjrk@gmail.com |
| |
Abstract: | Tachycardia has been associated with worse outcomes for patients with heart failure and is also thought to have a direct adverse
impact on the myocardium. This report highlights the current evidence for heart rate as both a risk factor and mediator for
poor outcome for patients with heart failure. We summarize the large number of studies evaluating heart rate in patients with
systolic dysfunction and newer studies that examine patients with preserved systolic function. The effect on outcomes in heart
failure of medications known to slow the heart rate such as β-blockers and the more recently developed drug ivabradine are
discussed. The data clearly show that a high heart rate is a marker of increased mortality. There is also a strong suggestion
that a higher heart rate directly worsens outcome and that this can be mitigated by heart rate–reducing medications. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |