Anti-PF4/heparin antibodies are associated with arteriovenous fistula thrombosis in non-diabetic hemodialysis patients |
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| Authors: | Yueh-Feng Tsai Chien-An Chen Chieh Kuo Kao-Chang Lin |
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| Affiliation: | (1) Department of Hemodialysis and Nephrology, Tainan Sinlau Hospital, Tainan, Taiwan;(2) Department of Biotechnology, Southern Taiwan University, Tainan, Taiwan;(3) Department of Cardiology, Tainan Sinlau Hospital, Tainan, Taiwan;(4) Department of Neurology, Chi-Mei Medical Center, No. 901, Zhonghua Rd, Yongkang, Tainan, Taiwan; |
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| Abstract: | Aim Anti-platelet factor 4/heparin complex antibodies (anti-PF4/heparin Ab) have been found to cause heparin-induced thrombocytopenia (HIT), a clinical syndrome thrombocytopenia and thrombosis. There is still controversy as to whether the presence of anti-PF4/heparin antibodies in hemodialysis patients augments clot formation in access fistula thrombosis, peripheral artery disease (PAD), and coronary heart disease (CHD). |
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