幽门螺杆菌相关性胃疾病MG7抗原的表达

目的 探讨幽门螺杆菌感染对MG7抗原动态表达的影响及意义。方法 采用免疫组化技术、PCR方法及ELISA方法,对291例胃黏膜的MG7抗原表达情况及幽门螺杆菌感染情况进行检测,并对34例幽门螺杆菌相关性胃疾病患者进行随访。结果 肠上皮化生、异型增生与萎缩性胃炎中,幽门螺杆菌感染阳性组和阴性组MG7抗原阳性表达率接近。浅表性胃炎中幽门螺杆菌阳性组MG7抗原阳性表达率显著高于阴性组（P＜0．05）。随访发现3例幽门螺杆菌阴性的病例中,1例变为阳性,并且MG7抗原表达亦相应变强;在31例幽门螺杆菌阳性的病例中,3例MG7抗原阳性者转变为早期胃癌,其中1例MG7抗原表达为强阳性者,经手术及化疗后,幽门螺杆菌转阴,MG7抗原表达亦转为弱阳性。结论 幽门螺杆菌感染与MG抗原阳性表达有一定的相关性。幽门螺杆菌阳性的MG7抗原阳性表达病例,具有较高恶变倾向。

MG7 expression in helicobacter pylori-related gastric diseases

Objective To determine the influence of Helicobacter py lori (H.py lori) on gastric cancer related antigen MG7 expression. Methods The H.py lori infection and the expression level of antigen MG7 in gastric mucos a were determi ned by HE stain, PCR, ELISA and immunohistochemistry in 291 patients with H.py lo ri related conditions, among whom 34 were followed up. Results No significa nt difference was found between H.py lori negative and H.py lori positive inte st inal metaplasia, atrophic gastritis and dy splasia of gastric epithelium in posit ive rate of antigen MG7 expression. There was significant difference between H.py lori negative and H.py lori positive superficial gastritis in the positiv e rate of MG7 expression ( P <0.05). During follow up, one of 3 H.py lori negative cases turned to be H.py lori positive, and its MG7 expression turned t o be higher at the same time. Three of 31 H.py lori positive patients were discovered as having early gastric cancer, among whom one with antigen MG7 expression ( ) was found to have a reduced Mg7 expression accompanied with H.py lori eliminutied after operation . Conclusion There is correlationship between H.py lori infection and MG7 expressio n in superficial gastritis. Although the MG7 positive lesions with H.py lori in f ection shows a benign nature in morphology , they also have the potential risK of developing into gastric cancer. Therefore, they should be followed up, during which special attention should be paid to patients with increased MG7 expression.