| 丰富环境对小鼠吗啡成瘾性的影响 |
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| 引用本文： | 徐志伟,侯冰,高艳,贺福初,张成岗.丰富环境对小鼠吗啡成瘾性的影响[J].中国药物依赖性杂志,2007,16(4):254-257. |
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| 作者姓名： | 徐志伟 侯冰 高艳 贺福初 张成岗 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,北京,100850 |
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| 基金项目： | 国家自然科学基金;国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的:研究丰富环境对小鼠吗啡成瘾性的影响。方法:40只♂小鼠随机分为丰富环境组(n=20)和普通环境组(n=20),利用行为敏化和条件性位置偏爱实验评价动物的精神依赖性。结果:丰富环境降低小鼠吗啡(10mg·kg-1)行为敏化的形成,阻断吗啡(5mg·kg-1)诱导的条件性位置偏爱的建立。结论:丰富环境可能对吗啡的精神依赖性具有干预作用。
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| 关 键 词： | 丰富环境 吗啡成瘾 行为敏化 条件性位置偏爱 |
| 收稿时间： | 2006-07-24 |
| 修稿时间： | 2006-10-30 |
EFFECTS OF ENRICHED ENVIRONMENT ON MORPHINE ADDICTION OF MICE |
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| XU Zhiwei,HOU Bing,GAO Yan,HE Fuchu,ZHANG Chenggang.EFFECTS OF ENRICHED ENVIRONMENT ON MORPHINE ADDICTION OF MICE[J].Chinese Journal of Drug Dependence,2007,16(4):254-257. |
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| Authors: | XU Zhiwei HOU Bing GAO Yan HE Fuchu ZHANG Chenggang |
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| Abstract: | Objective:To investigate the effects of enriched environment (EE) on morphine addiction. Methods:Forty male mice were divided into enriched environment group(n=20) and standard environment group(n=20). Behavioral sensitization and conditioned place preference (CPP) experiments were used to measure the opiate psychological dependence. Results:Enriched environment significantly attenuated morphine (10 mg·kg-1)-induced behavioral sensitization in mice, and blocked morphine (5 mg·kg-1)-induced CPP. Conclusion:EE might be useful in the treatment of opiate psychological dependence. |
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| Keywords: | enriched environment morphine addiction behavioral sensitization conditioned place preference |
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