盐酸纳美芬联合清开灵注射液在急性安眠药中毒抢救中的应用

目的观察盐酸纳美芬联合清开灵注射液治疗急性安眠药中毒的临床疗效。方法选取90例急性安眠药中毒的患者并采用信封法随机分为2组,每组45例,所有患者确诊后均给予安定中毒常规治疗,包括输液、利尿、维持电解质平衡、吸氧等。对照组在常规治疗基础上给予盐酸纳美芬0.5μg/kg静脉滴注,观察组在对照组基础上给予1～2 mg/kg清开灵注射液滴注,qd。治疗期间严密观察两组患者意识、呼吸及各种反射,监测生命体征,并进行疗效评定。观察两组患者治疗后意识清醒时间,详细记录并比较两组患者住院天数。结果观察组治疗总有效率为95.56%,对照组为82.22%,观察组治疗总有效率明显高于对照组(P<0.05)。观察组治疗后意识清醒时间及住院时间分别为(5.04±2.35)h、(4.56±1.58)d,对照组分别为(7.56±2.85)h、(6.87±2.05)d,观察组意识清醒时间及住院时间均明显少于对照组(P<0.05)。结论盐酸纳美芬联合清开灵注射液治疗急性安眠药中毒,两药协同,可明显提高治疗效果,缩短病程。

Application of hydrochloride nalmefene combined with Qingkailing injection in thefirst aid to acute hypnotic poisoning

Objective To observe the clinical efficacy of nalmefene combined with Qingkailing injection in the first aid to acute hypnotic poisoning. Methods 90 cases of acute poisoning patients using sleeping pills were ran- domly divided into two groups by envelopes ,45 cases in each group, all patients were given conventional treatment of poisoning after diagnosis,including infusion, diuretic, maintain electrolyte balance, oxygen and so on. Treatment group was given hydrochloride nalmefene 0. 5μg/kg intravenously on the basis of conventional treatment, observation group was given 1 -2 mg/kg Qingkailing injection, qd, on the basis of treatment group. The patients＇ consciousness, breathing and various reflections were closely observed during the treatment, vital signs were monitored, and efficacy was evalua- ted. Conscious time of the two groups was observed after treatment, and hospitalization time was recorded and com- pared. Results The total effective rate of observation group and control group were 95.56% and 82. 22% , the total ef- fective rate of observation group was significantly higher than that of control group （ P 〈 0. 05 ）. After treatment, the conscious time and hospitalization time of observation group were （ 5.04 ± 2. 35 ） h and （ 4. 56 ± 1. 58 ） d, control group were （7.56 ± 2. 85 ） h and （ 6. 87 ± 2. 05 ） d, the conscious time and hospitalization time of observation group were significantly less than those of control group （ P 〈 0. 05 ）. Conclusion Hydrochloride nalmefene combined with Qingkailing injection in the treatment of acute hypnotic poisoning can significantly improve the therapeutic effect and shorten the course.