体素内不相干运动扩散加权成像在良性脑膜瘤中的初步研究 |
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引用本文: | 李玉超,王光彬,刘 强,等. 体素内不相干运动扩散加权成像在良性脑膜瘤中的初步研究[J]. 医学影像学杂志, 2014, 0(3): 461-464,473 |
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作者姓名: | 李玉超 王光彬 刘 强 等 |
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作者单位: | [1]山东大学医学院山东省医学影像学研究所MR室,山东济南250021 [2]潍坊医学院,山东潍坊261042 [3]飞利浦医疗保健事业部,上海200233 |
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摘 要: | 目的 探讨多b值体素内不相干运动扩散加权磁共振成像(introvoxel incoherent motion MR imaging,IVIM MRI)的单、双指数模型在良性脑膜瘤中的应用价值.方法 纳入22例手术病理证实为良性脑膜瘤并术前行常规MR序列及IVIM序列扫描的患者.多b值IVIM序列包括14个b值(0~1 000s/mm2),所得IVIM序列原始数据经单、双指数模型处理,得到单、双指数模型衰减曲线,并生成对应参数图,测量肿瘤实质区及正常脑白质的单指数模型的扩散系数ADC值和双指数模型的扩散系数D值、灌注分数f值、灌注系数D*值,采用配对样本t检验进行统计学分析.结果 单、双指数模型衰减曲线显示肿瘤实质区信号强度随b值的增大而衰减.肿瘤实质区ADC值、D值、D*值、f值分别为(0.87±0.13)μm2/ms、(0.79±0.10)μm2/ms、(58.68±27.52)μm2/ms、(7.68±3.59)%;正常脑白质的ADC值、D值、D*值、f值分别为(0.74±0.06)μm2/ms、(0.69±0.04)μm2/ms、(93.43±31.64)μm2/ms、(4.48±2.39)%.单指数模型中肿瘤实质区ADC值较正常脑白质ADC值两者比较差异有统计学意义(t=5.793,P<0.05);双指数模型中,肿瘤实质与正常脑白质D、f、D*值分别进行比较,肿瘤实质的D、f值均较正常脑白质增高(t=4.384,P<0.05和t=3.349,P<0.05);而肿瘤实质D*值较正常脑白质D*值减低(t=-3.559,P<0.05).肿瘤实质区单指数模型ADC值与双指数模型D值两者差异有统计学意义,且单指数ADC值显著较双指数模型D高(t=6.492,P<0.05).结论 基于棠规DWI序列的多b值IVIM双指数模型可以更准确地描述良性脑膜瘤的扩散信息,同时非侵入性地获得肿瘤灌注信息.
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关 键 词: | 磁共振成像 多b值 体素内不相干运动 扩散加权成像 脑膜瘤 |
The pilot study of benign meningiomas using intravoxel incoherent motion imaging |
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Affiliation: | LI Yu-chao,WANG Guang-bin,LIU Qiang,SHI Hong-lu,HAO Wen,YANG Li,LI Li-li( 1.School of Medicine, Shandong University, Shandong Medical Imaging Research Institute, Jinan Shandong 250021,P.R. China; 2.Weifang Medical University, Weifang Shandong 261042, P.R. China;) |
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Abstract: | Objective To evaluate the diagnostic performance of monoexponential model and the bi-exponential modeling of intravoxel incoherent motion (IVIM) MR imaging for benign meningiomas in brain.Methods All patients in this study provided written informed consent to the scanning.Twenty-two patients with histologically proven benign meningiomas were examined on a 3.0T MR seanners(Achieva 3.0 T TX,Philips,The Netherlands).The scanning protocol included the conventional MR imaging,IVIM MR imaging and contrast-enhanced MR imaging.The IVIM sequence was performed with 14b values between 0 and 1 000 s/mm2 on 3 orthogonal directions.Region-of-interest was manually set on the tumor as well as in the normal white matter.All the data were fitted by a monoexponential model [yielding the apparent diffusion coefficient (ADC)] and the bi-exponential model (yielding the diffusion constant D,the pseudodiffusion coefficient of perfusion D * and the perfusion fraction f).The paired t tests were used to assess differences between the tumor and normal white-matter.Results Signal decay curves were bi-exponential in the benign meningiomas.The ADC,D,D* and f values of benign meningiomas were (0.87±0.13) μm2/ms,(0.79±0.10) μm2/ms,(58.68±27.52) μm2/ms,(7.68±3.59)% and those values of the normal white-matter were (0.74±0.06) μm2/ms,(0.69±0.04) μm2/ms,(93.43±31.64) μm2/ ms,(4.48±2.39) %,respectively.The differences of the ADC,D,D* and f values between two groups were statistically significant (t =5.793,4.384,-3.559,3.349; P <0.05,respectively).The differences of the ADC and the D values between the benign meningiomas parenchyma were statistically significant (t =0.579,P <0.05).Conclusion IVIM imaging might be a valid and promising method to quantify perfusion and more accurate diffusion in benign meningiomas. |
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Keywords: | MRI Multi-b value IVIM Diffusion weighted imaging Meningiomas |
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