Coronary artery calcium scoring: diagnostic accuracy of different software implementations |
| |
Authors: | Knollmann Friedrich D Helmig Klaus Kapell Susanne Hummel Manfred Bocksch Wolfgang Hetzer Roland Felix Roland |
| |
Affiliation: | Department of Radiology, Charité, Campus Virchow-Klinikum, Humboldt-University, Berlin, Germany. Friedrich.Knollman@charite.de |
| |
Abstract: | PURPOSE: To compare the diagnostic power of different software implementations for the quantification of coronary artery calcium. MATERIALS AND METHODS: Electron beam computed tomography was performed in 109 heart transplant recipients at the same time as catheter coronary angiography and intracoronary ultrasound. Electron beam computed tomography images were analyzed by 3 software packages marketed for the quantification of coronary calcifications using the same software settings, and the resultant calcium scores correlated with the invasive reference methods by Bland-Altman plots and analysis of the receiver operating characteristics. RESULTS: Although all scoring systems displayed close correlations upon regression analysis (r2=0.94-0.99), their ability to detect disease as per the invasive reference method varied significantly in some instances. The area under the ROC curve varied between Az=0.78 and 0.85 for the detection of coronary artery stenosis upon coronary angiography (P=0.05-0.13), and between Az=0.75 and 0.83 for the detection of accelerated intimal proliferation (P=0.03-0.18). CONCLUSIONS: Different software implementations for the quantification of coronary artery calcium load may display diagnostically relevant differences in spite of close direct correlation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|