| 不同程度铅中毒大鼠模型的制备 |
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| 引用本文： | 牛廷献,哈小琴. 不同程度铅中毒大鼠模型的制备[J]. 西北国防医学杂志, 2009, 30(1): 32-33 |
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| 作者姓名： | 牛廷献 哈小琴 |
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| 作者单位： | 1. 兰州军区兰州总医院 动物实验科,甘肃,兰州,730050
2. 兰州军区兰州总医院 实验科,甘肃,兰州,730050 |
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| 摘 要： | 目的：建立不同程度大鼠铅中毒模型。方法：Wistar大鼠分别自由饮用不同浓度的醋酸铅1、3、6个月，以原子吸收法测定全血和脑匀浆液的铅水平。结果：实验组全血和脑匀浆中的铅水平均明显高于对照组（P〈0．01），且二者的铅水平随染铅时问的延长、浓度的增加均明显升高（P〈0．05）。结论：以不同时间、不同浓度染铅均成功地建立了大鼠铅中毒模型。
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| 关 键 词： | 铅中毒 动物模型 大鼠 |
Establishment of plumbism rat model at different-degree |
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| NIU Ting-xian,HA Xiao-qin. Establishment of plumbism rat model at different-degree[J]. Medical Journal of National Defending Forces in Northwest China, 2009, 30(1): 32-33 |
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| Authors: | NIU Ting-xian HA Xiao-qin |
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| Affiliation: | NIU Ting - xian, HA Xiao - qin. ( Department of Animal Experiment, Lanzhou General Hospital, Lanzhou Command, PLA, Lanzhou 730050, China) |
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| Abstract: | Objective：To establish the plumbism model of rat at different degree. Methods： Wistar rats freely drank plumbic acetas of different - concentration for 1, 3 and 6 months respectively. Then the plumbum contents were determined by atomic absorption method in the whole blood and brain homogenate. Results： The plumbum contents in the whole blood and brain homogenate in the experiment groups were significantly higher than those in the control group （ P 〈 0. 01 ）, and they stepped up obviously with the longer plumbum exposure time and the higher concentration （P 〈 0. 05 ）. Conclusion： The plumbism rat model can be established successfully by plumbum intake with different exposure time and concentration. |
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| Keywords: | Plumbism Animal model Rat |
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