Association between adiponectin gene polymorphisms and coronary artery disease across different populations |
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Authors: | Zhou Liang Xi Bo Wei Yuan Pan Haiyan Yang Wanshui Shen Weihua Li Yixiang Cai Jianguang Tang Hui |
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Institution: | a Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, Chinab Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, Chinac Department of Sports Physiology, Guangzhou Sports University, Guangzhou 510075, Chinad Department of Epidemiology and Biostatistics, Guangdong Medical College, Dongwan 523808, Chinae Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China |
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Abstract: | ObjectiveMany studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the associations of + 45T/G, + 276G/T and − 11377C/G polymorphisms in adiponectin gene with CAD susceptibility.MethodsPublished literature from PubMed and EMBASE databases were searched. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed- or random-effects model.ResultsSixteen studies (4394 cases / 8187 controls) for + 45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for + 276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for − 11377C/G polymorphism were included in the meta-analysis. The overall results showed that there was a statistically significant association between − 11377C/G polymorphism and CAD (G vs. C: OR = 1.15, 95%CI 1.07-1.24).Similar results were observed among European (G vs. C: OR = 1.11, 95%CI 1.02-1.20) and East Asian populations (G vs. C: OR = 1.27, 95%CI 1.11-1.45). However, no significant association was found for + 45T/G or + 276G/T polymorphism with CAD susceptibility.ConclusionsThe meta-analysis indicated the significant association of − 11377C/G polymorphism, but not + 45T/G or + 276G/T polymorphism, with CAD susceptibility. However, large-scale studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the associations in future. |
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Keywords: | Adiponectin Polymorphism Coronary artery disease Meta-analysis |
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