注射用益气复脉（冻干）联合西药治疗冠心病心绞痛的系统评价和Meta分析

目的] 系统评价注射用益气复脉（冻干）联合西药常规治疗冠心病心绞痛的临床疗效与安全性。方法] 计算机检索中国知网（CNKI）、万方数据库（WanFang Data）、维普（VIP）、Embase、Pubmed、The Cochrane Library数据库，搜集关于注射用益气复脉（冻干）联合西药常规治疗心绞痛的随机对照试验，检索时限从建库至2018年12月。由两位评价员独立筛选文献、提取资料，如有分歧，讨论解决，采用RevMan 5.3进行数据分析。结果] 共纳入5篇文献（4项临床研究），383例患者，Meta分析结果显示：在改善心电图疗效方面，注射用益气复脉（冻干）联合西药常规治疗优于西药常规对照组RR=1.27，95% CI（1.12，1.44），P<0.05]，未发生严重不良反应。结论] 鉴于纳入研究数量较少，质量不高，尚不能说明注射用益气复脉（冻干）联合西药常规治疗疗效优于单纯西药常规治疗，仍需通过多项随机对照、多中心、大样本的高质量临床试验予以验证。

Systematic review and Meta-analysis of Yiqi Fumai Lyophilized Injection combined with Western medicine in treating coronary heart disease angina pectoris

Objective] To systematically evaluate the efficacy and safety of Yiqi Fumai Lyophilized Injection combined with Western medicine in treating coronary heart disease angina pectoris.Methods] CNKI, WanFang Data, VIP, Embase, Pubmed, the Cochrane Library databases were used to collect randomized controlled trials (RCTs) of Yiqi Fumai Lyophilized Injection combined with Western medicine for angina pectoris. The search time limit was from the establishment of the database to December 2018. Two evaluators independently screened the literature and extracted the data. If there were any differences, they discussed and solved them. RevMan 5.3 was used for data analysis.Results] A total of 5 literatures (4 clinical studies) and 383 patients were included. Meta-analysis showed that Yiqi Fumai Lyophilized Injection combined with Western medicine was superior to Western medicine routine control group in improving the effect of electrocardiogram (ECG)RR=1.27, 95%CI (1.12, 1.44), P<0.05], and no serious adverse reactions occurred.Conclusion] In view of the small number and low quality of the included studies, it cannot be said that the curative effect of Yiqi Fumai Lyophilized Injection combined with Western medicine is better than that of Western medicine routine treatment alone, and it still needs to be verified by a number of randomized controlled, multicenter and large sample high-quality clinical trials.