癫狂梦醒汤联合黛力新治疗气滞血瘀型脑梗死后抑郁症临床观察

目的] 观察癫狂梦醒汤联合黛力新治疗气滞血瘀型脑梗死后抑郁症患者的临床疗效。方法] 将100例符合纳入标准的患者随机分为治疗组、对照组各50例，治疗过程中两组分别剔除、脱落6例，最终完成治疗组、对照组各44例。对照组予以缺血性脑卒中常规及对症治疗，并联合应用黛力新，治疗组在此基础上给予癫狂梦醒汤，服药疗程为8周。两组分别进行汉密尔顿抑郁评定（HAMD）量表、美国国立卫生研究院卒中（NIHSS）量表、不良反应量表（TESS）、中医证候积分以及5-羟色胺（5-HT）的评定及对比。结果] 治疗后，治疗组总有效率、5-HT水平均优于对照组，治疗组患者抑郁情绪、神经功能缺损程度、临床症状均较前改善，且药物不良反应发生率低于对照组，有统计学差异或显著统计学差异（P<0.05或P<0.01）。结论] 该临床观察显示癫狂梦醒汤能够有效改善气滞血瘀型脑梗死后抑郁症患者的抑郁情绪，且疗效优于单纯应用黛力新治疗。

Clinical observation on the treatment of post-stroke depression of qi stagnation and blood stasis type with Diankuang Mengxing Decoction and Deanxit

Objective] To observe the clinical efficacy of Diankuang Mengxing Decoction combined with Deanxit in the treatment of post-stroke depression of qi stagnation and blood stasis type.Methods] One hundred patients meeting the inclusion criteria were randomly divided into the treatment group and the control group with 50 cases each. During the treatment,6 cases were removed and dropped from the two groups respectively,and 44 cases in the treatment group and the control group were finally completed. The control group was given routine and symptomatic treatment of ischemic stroke,combined with Deanxit. On this basis,the treatment group was given Diankuang Mengxing Decoction for 8 weeks. Hamilton Depression Rating Scale(HAMD),National Institutes of Health Stroke Scale (NIHSS),side effects scale (TESS),traditional Chinese medicine (TCM) syndrome score and 5-hydroxytry-ptamine (5-HT) were assessed and compared in the two groups.Results] After treatment, the total effective rate and the level of 5-HT in the treatment group were better than those in the control group. The depression, neurological deficit and clinical symptoms of the treatment group were improved, and the incidence of adverse drug reactions was lower than that of the control group (P<0.05 or P<0.01).Conlution] The clinical observation shows that Diankuang Mengxing Decoction can improve the depressive mood of patients with Post-stroke depression of qi stagnation and blood stasis type,and its curative effect is better than that of Deanxit alone.