| LC-MS/MS法测定人血浆中地高辛的浓度及其在儿童患者中的应用 |
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| 引用本文： | 夏颖,龙佳奕,代浩然,沈梦元,郭宏丽,胡雅慧,陈峰.LC-MS/MS法测定人血浆中地高辛的浓度及其在儿童患者中的应用[J].中国药科大学学报,2021,52(6):719-724. |
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| 作者姓名： | 夏颖 龙佳奕 代浩然 沈梦元 郭宏丽 胡雅慧 陈峰 |
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| 作者单位： | 南京医科大学附属儿童医院药学部药学研究中心，南京 210008,中国药科大学础医学与临床药学学院，南京 210009,中国药科大学础医学与临床药学学院，南京 210009,南京医科大学康达学院，连云港 222000,南京医科大学附属儿童医院药学部药学研究中心，南京 210008,南京医科大学附属儿童医院药学部药学研究中心，南京 210008,南京医科大学附属儿童医院药学部药学研究中心，南京 210008 |
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| 基金项目： | 江苏卫生健康委员会特聘医学专家项目资助（2019）#南京医科大学康达学院本科实习生 |
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| 摘 要： | 建立了简单、快速、可靠的LC-MS/MS法测定人血浆中地高辛的浓度.以地高辛-d3为内标,血浆样品经液液萃取法处理后进样.色谱柱为Kinetex C18(2.1 mm×50 mm,2.6 μm;Phenomenex),流动相为均含1 mmol/L醋酸铵和1 mmol/L甲酸的水溶液和乙腈溶液(55∶45),采用等度洗脱...
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| 关 键 词： | 地高辛 LC-MS/MS 儿童 含量测定 |
| 收稿时间： | 2021/8/24 0:00:00 |
| 修稿时间： | 2021/11/4 0:00:00 |
Determination of digoxin in human plasma by LC-MS/MS and its application in pediatric patients |
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| XIA Ying,LONG Jiayi,DAI Haoran,SHEN Mengyuan,GUO Hongli,HU Yahui and CHEN Feng.Determination of digoxin in human plasma by LC-MS/MS and its application in pediatric patients[J].Journal of China Pharmaceutical University,2021,52(6):719-724. |
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| Authors: | XIA Ying LONG Jiayi DAI Haoran SHEN Mengyuan GUO Hongli HU Yahui and CHEN Feng |
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| Institution: | Pharmaceutical Sciences Research Center, Department of Pharmacy, Children''s Hospital of Nanjing Medical University, Nanjing 210008,School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009,School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009,Kangda College of Nanjing Medical University, Lianyungang 222000 ,China,Pharmaceutical Sciences Research Center, Department of Pharmacy, Children''s Hospital of Nanjing Medical University, Nanjing 210008,Pharmaceutical Sciences Research Center, Department of Pharmacy, Children''s Hospital of Nanjing Medical University, Nanjing 210008,Pharmaceutical Sciences Research Center, Department of Pharmacy, Children''s Hospital of Nanjing Medical University, Nanjing 210008 |
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| Abstract: | |
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| Keywords: | digoxin LC-MS/MS children determination of contents |
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