| 代谢型谷氨酸受体5在中枢神经系统疾病中的研究进展 |
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| 引用本文： | 朱恩妮,吴超然,廖红. 代谢型谷氨酸受体5在中枢神经系统疾病中的研究进展[J]. 中国药科大学学报, 2021, 52(6): 751-758 |
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| 作者姓名： | 朱恩妮 吴超然 廖红 |
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| 作者单位： | 中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009,中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009,中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目（No.82073831） |
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| 摘 要： | 代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mGluR5)是中枢谷氨酸能系统的重要受体之一,其广泛参与调控突触传递、突触可塑性、神经兴奋性/抑制性平衡等生理过程.多项研究发现,mGluR5参与介导不同神经和精神疾病的发生发展,因此其作为神经和精神疾病的潜在药物靶标日益受到关注...
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| 关 键 词： | 代谢型谷氨酸受体5 生理功能 中枢神经系统疾病 药物研发 进展 |
| 收稿时间： | 2021-05-07 |
| 修稿时间： | 2021-10-26 |
Research progress of metabotropic glutamate receptor 5 in related central nervous system diseases |
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| ZHU Enni,WU Chaoran and LIAO Hong. Research progress of metabotropic glutamate receptor 5 in related central nervous system diseases[J]. Journal of China Pharmaceutical University, 2021, 52(6): 751-758 |
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| Authors: | ZHU Enni WU Chaoran LIAO Hong |
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| Affiliation: | New Drug Screening Center,Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China,New Drug Screening Center,Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China,New Drug Screening Center,Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | As a key component of glutamatergic system, metabotropic glutamate receptor 5 (mGluR5) has been extensively involved in the regulation of physiological processes such as synaptic transmission, synaptic plasticity and synaptic excitation/inhibition balance.Over the past few decades, mGluR5 has been found to be closely related to multiple neurological and psychiatric disorders, thus it is of considerable interest as a drug target in the treatment of such disorders.This review summarizes the structure and distribution of mGluR5, its normal physiological function, its pathological roles in related central nervous system (CNS) diseases, as well as the current status of its drug development, in order to provide reference for further investigation. |
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| Keywords: | metabotropic glutamate receptor 5 physiological function central nervous system diseases drug development advances |
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