| 单-ADP核糖转移酶家族及其抑制剂在肿瘤治疗中的研究进展 |
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| 引用本文： | 李茵,古宏峰,邹毅,王淑平,徐云根.单-ADP核糖转移酶家族及其抑制剂在肿瘤治疗中的研究进展[J].中国药科大学学报,2021,52(6):643-652. |
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| 作者姓名： | 李茵 古宏峰 邹毅 王淑平 徐云根 |
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| 作者单位： | 中国药科大学药物化学系,南京 211198,中国药科大学药物化学系,南京 211198,中国药科大学药物化学系,南京 211198,中国药科大学药物化学系,南京 211198,中国药科大学药物化学系,南京 211198 |
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| 基金项目： | 国家自然科学基金资助项目（No.81502928）;江苏省优秀科技创新团队资助项目（2015） |
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| 摘 要： | 多聚腺苷二磷酸核糖聚合酶(PARPs)在DNA修复与细胞凋亡中发挥着重要的作用.该酶家族中有一类PARPs通过催化和转移单个ADP-核糖来调控各种细胞反应,被称为单-ADP核糖转移酶(MARTs).大部分MARTs在肿瘤中过度表达,与肿瘤的发生发展密切相关.本文重点介绍了在肿瘤中过度表达的MARTs,以其结构域的差异进...
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| 关 键 词： | ADP-核糖化 MARTs MARTs抑制剂 肿瘤治疗 进展 |
| 收稿时间： | 2021/5/6 0:00:00 |
| 修稿时间： | 2021/5/31 0:00:00 |
Research progress of mono-(ADP-ribosyl) transferase family and their inhibitors in tumor therapy |
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| LI Yin,GU Hongfeng,ZOU Yi,WANG Shuping and XU Yungen.Research progress of mono-(ADP-ribosyl) transferase family and their inhibitors in tumor therapy[J].Journal of China Pharmaceutical University,2021,52(6):643-652. |
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| Authors: | LI Yin GU Hongfeng ZOU Yi WANG Shuping and XU Yungen |
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| Institution: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | Poly-adenosine diphosphate ribose polymerases (PARPs) play an important role in DNA repair and apoptosis.Among them, mono-(ADP-ribosyl) transferase (MARTs) can regulate various cell reactions by catalyzing and transferring single ADP-ribose.Most MARTs are highly expressed in cancers, which is closely related to the occurrence and progression of cancers.This review introduces the MARTs that are highly expressed in cancers, classifies them according to the differences of their structural domains, and reviews their known mechanism, their close relationship with cancers, their potential value in cancer therapy and the research progress of corresponding inhibitors.These targets are expected to provide new research ideas for cancer therapy in the era of precision medicine. |
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| Keywords: | ADP-ribosylation MARTs MARTs inhibitor tumor therapy advances |
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