慢性脑供血不足的内皮功能变化及药物干预的影响

目的探讨慢性脑供血不足(CCCI)的发病机制和病理过程及药物干预对内皮功能的影响。方法根据日本2000年修订的CCCI诊断标准选择研究对象90例,将其分为基础治疗组(A组)、养血清脑颗粒组(B组)、联合用药组(C组)各30例,同时选正常对照组(D组)27例,用药前后测定血清一氧化氮(NO)、血管内皮素-1(ET-1)水平,检测血管内皮功能,并进行统计学分析。结果A、B、C组治疗前分别与D组比较,NO水平降低,ET-1水平升高,差异有统计学意义(P均<0.01);A组治疗前后比较,血清NO、ET-1水平及内皮依赖性血管舒张功能(EDD)差异均无统计学意义,而B、C 2组治疗后各指标水平均较治疗前有改善(P<0.01),非内皮依赖性血管舒张功能(NEDD)在A、B、C 3组治疗前后无差异;治疗后B、C 2组各指标比较差异均无统计学意义,但分别与A组比较,除NEDD(P>0.05)外其他各指标差异均有统计学意义(P<0.01)。结论CCCI患者存在内皮功能异常,而养血清脑颗粒能够调节血管活性物质水平,改善EDD。

Endothelium metergasis of chronic cerebral circulation insufficiency and the effects of drugs intervention

Objective To explore the pathogenesis and pathological process of chronic cerebral circulation insufficiency(CCCI) and the effects of drugs intervention on endothelium function.Methods Ninty CCCI patients were selected as research objects according to the diagnostic criteria of CCCI revised in Japan 2000.They were divided into three groups equally,treated by basis method of group A,Yangxue Qingnao granule of group B and drug combination of group C respectively,at the same time,27 healthy persons were selected as control group(group D) with no special treatment.Levels of serum NO,ET-1 and functions of vascular endothelium before and after medication were tested and analyzed.Results It was found that before the treatment,the levels of serum NO in group A,B,C decreased significantly compared with that in group D,and levels of serum ET-1 increased.The levels of serum NO,ET-1,EDD and NEDD before and after the intervention in group A showed no significant difference.Yet the differences of these markers except NEDD between group B and C were significant.These markers in group B and C were improved more significantly after the treatment than that in group A.Conclusion There is endothelium disfunction in the patients with CCCI,and Yangxue Qingnao granule could regulate the levels of vasoactive substances and improve EDD.