减体重对肥胖和超重者心血管病危险因素的影响

目的：探讨对肥胖和超重者的减肥对心血管危险因素的影响。方法：对41名肥胖和超重者采取6周封闭管理的集中减肥，控制饮食，进行运动训练，每2周测定体重、腰臀围等指标，减肥前、后进行空腹血脂、血糖、血胰岛素、血转氨酶及肝脏超声检查。结果：通过6周减肥，受试者的体重、体重指数、腰围、臀围、腰臀围比、皮褶厚度、体脂含量及百分比、静息血压、心率呈非常明显的下降（P〈0．001）：减肥后血丙氨酸氨基转移酶、甘油三酯、胰岛素及胰岛素抵抗指数明显下降（P〈0．05-〈0．001），血高密度脂蛋白-胆固醇明显升高（P〈0．001），脂肪肝显著改善（P=0．001）。结论：运动锻炼结合饮食控制可减轻肥胖和超重者的体重，有效降低心血管疾病的危险因素。

Effects of weight reduction on risk factors of cardiovascular disease in persons with obesity and overweight

Objective: To observe the effects of weight reduction on risk factors of cardiovascular disease in persons with obesity and overweight by exercise and energy intake controlling. Methods: An organized,closed disease program with exercise and energy intake controlling (weight reduction) for 6 weeks were taken for 41 subjects with obesity and overweight. Weight, waist circumference etc. were measured every 2 weeks. The lipid, glucose etc. in fasting blood and the ultrasonography for fatty liver were examined before and after the program. Results: After 6 weeks weight reduction, the weight, body mass index, waist circumference, hip circumference, waist hip ratio, thickness of skin fold, fat mass and body fat percentage, rest heart rate, rest blood pressure of subjects were diminished significantly (P<0. 001). The blood triglyceride, insulin, alanine aminotransferase and insulin resistance index decreased significantly (P<0. 05-<0. 001) , the blood high density lipoprotein cholesterol increased (P<0. 001) ; the degree of fatty liver significantly ameliorated (P = 0. 001) in subjects. Conclusion: The cardiovascular risk factors of persons accompanied with obese or overweight can efficiently be attenuated by exercise and diet controlling (weight reduction).