Rapid equilibration of warfarin between rat tissue and plasma |
| |
| Authors: | Theodore J. Benya John G. Wagner |
| |
| Affiliation: | (1) Present address: College of Pharmacy, Ohio Northern University, 45810 Ada, Ohio;(2) College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, 48104 Ann Arbor, Michigan |
| |
| Abstract: | Plasma and tissue concentrations of warfarin in the rat were measured as a function of time following a 10 mg/kg intravenous dose. The mathematical interpretation of the experimental results suggested that the data could be explained in terms of a two-compartment open model. Following equilibration, which occurred within a few minutes after injection, individual tissue levels and plasma levels of warfarin were found to be always directly proportional.Supported by Training Grant GM 1367-10 from the National Institute of General Medical Sciences, U.S. Public Health Service, Bethesda, Maryland 20014. |
| |
| Keywords: | warfarin linear pharmacokinetics tissue binding plasma protein binding tissue distribution |
| 本文献已被 SpringerLink 等数据库收录！ |
|
