Comparative study of uniform design and orthogonal design in the extraction of Gelsemium alkaloids] |
| |
| Authors: | Lan-lan Zhang Chang-quan Huang Zhong-yi Zhang Jing-ming Lin |
| |
| Affiliation: | Department of Pharmaceutics, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. |
| |
| Abstract: | OBJECTIVE: To develop a simple and efficient method for extracting Gelsemium alkaloids. METHODS: Uniform design and orthogonal design were respectively utilized to optimize the 3 factors in the extraction process, namely the type of solvent used, the solid-to-liquid ratio in the extraction system and the reflux time. RESULTS: Both of the design methods adopted trichloromethane as the solvent, with the solid-to-liquid ratio of 1:7.5 and reflux time of 3 h with 3 repetitions for the highest yield of alkaloids. CONCLUSION: Similar results are obtained from the two design methods for extracting Gelsemium alkaloids. |
| |
| Keywords: | |
|
|
