中日友好医院铜绿假单胞菌临床感染分布及其耐药性分析

目的：分析我院２ａ来铜绿假单胞菌医院感染分布及其对不同类型抗生素的耐药情况。方法：对我院各病房送检的痰、尿、分泌物等标本进行细菌培养，并采用肉汤稀释法对头孢菌素类、氨基糖甙类等１１种抗生素进行药物最低抑菌浓度分析。结果：痰标本中铜绿假单胞菌分离率为１１１％，分泌物中为１５４％；菌株的１９５％分布在重症监护病房，１５５％分布在西医甲级病房；抗生素耐药率分别为头孢唑啉９８％、头孢哌酮２２％、头孢他啶１２４％、环丙沙星２０％、庆大霉素３２１％等。结论：铜绿假单胞菌仍是我院细菌感染的主要致病菌之一，主要发生在免疫力低下的老年危重患者中，且对多种不同类型的抗生素耐药，临床应加强合理应用抗生素以减少耐药菌株的产生

P .AERUGINOSA NOSOCOMIAL INFECTION IN CHINA JAPAN FRIENDSHIP HOSPITAL AND ANTIBIOTIC RESISTANCE ANALYSIS

Objective:To investigate Pseudomonas aeruginosa nosocomial distribution in China Japan Friendship Hospital and the susceptibility to differentiate antimicrobial agents.Methods:Sputum,urine,pus and other samples from different wards were cultured for bacterium,and antibiotic susceptibility was studied by using the broth microdilution method.Results:11 1% of P .aeruginosa was found from sputum,and 15 4% from secretion.19 5% of P .aeruginosa was isolated in ICU.15 5% in A 14 ward.Antibiotic resistant rate was cefzolin 98%,cefperazone 22%,ceftazidime 12 4%,ciprofloxacin 20%,gentamycin 32 1%,respectively.Conclusion: P .aeruginosa still is major pathogenic bacteria in China Japan Friendship Hospital,mainly existing in immuno compromised elder patients.With resistanlce to a variety of antimicrobial agents.Third generation cephalosporin and Amikacin showed better antipseudomonial activity.