IL-6、CRP和CD64在新生儿感染性疾病诊断中的价值

目的： 探讨白介素6(IL-6)、C反应蛋白(CRP)、中性粒细胞表面标志物CD64在新生儿感染性疾病中的诊断价值。方法： 选取宜兴市人民医院新生儿科2005年1月至2011年12月收住的107例患儿进行回顾性分析，107例患儿分为败血症组35例，非细菌感染组30例，健康对照组42例，对3组间IL-6、CRP阳性率及CD64水平进行比较。结果： 败血症组、非细菌感染组及健康对照组CRP阳性率分别为80.0%、63.3%和23.8%，败血症组与健康对照组之间、非细菌感染组与健康对照组间差异均有统计学意义。3组IL-6阳性率分别为85.7%、33.3%和9.5% ，败血症组与非细菌感染组、败血症组与健康对照组间差异均有统计学意义(P均<0.05)。3组间CD64水平差异有统计学意义（H=77.818，P<0.01），败血症组明显高于健康对照组和非细菌感染组（P均<0.05）。联合检测IL-6+CRP+CD64对新生儿败血症的特异性为94.6%，与IL-6、CRP、CD64、IL-6+CD64、CRP+CD64间差异均有统计学意义（P均<0.05）。结论: 联合检测IL-6+CRP+CD64可提高对细菌感染的特异性，为临床工作提供早期诊断依据。

Clinical significance of interleukin 6,C-reactive protein,neutrophil cell surface marker CD64 in the diagnostic value of neonatal infections

Objective: To explore clinical significance of the interleukin 6(IL-6),C-reactive protein(CRP),neutrophil cell surface marker CD64 in the diagnostic value of neonatal infections.Methods: The information of 107 cases were analyzed retrospectively;they were from Yixing people′s hospital,department of neonatology,admitted in January 2005 to December 2011.They were divided into 35 cases of sepsis group,30 cases of non-bacterial infection,42 cases of healthy newborns.Positive rate of IL-6 and CRP,and CD64 levels were analyzed.Results: CRP-positive rate of sepsis group、 non-bacterial infection group and the healthy control group was 80%,63.3%,23.8% respectively.There were significant differences between the septicemia group and the healthy control group,or the non-bacterial infection group and the healthy control group(all P<0.05).IL-6 positive rate of the three groups was 85.7%,33.3%,9.5% respectively,and the differences were statistically significant between the sepsis group and non-bacterial infection,or sepsis group and the healthy control group(all P<0.05).The CD64 level differences among the three groups was statistically significant(H= 77.818,P<0.01).Specificity of the combined detection IL-6+CRP+CD64 were 94.6%,and the differences were statistically significant compared to IL-6,CRP,CD64,IL-6+ CD64,CRP+CD64(all P<0.05).Conclusion: Combined detection of IL-6,CRP and CD64 will increase the specificity of bacterial infection diagnosis,and it will provide an early diagnostic marker for clinical work.