Glycodelin—A与人类生殖

Glycodelin-A是由分泌期的子宫内膜合成并于妊娠早期在子宫内膜腺体中表达的重要的糖蛋白,其合成受到多种激素的调节。随着对Glycodelin-A研究的深入,Glycodelin-A与人类生殖的关系显得愈加密切。Glycodelin-A具有抑制精卵结合的作用,其在围排卵期子宫内膜中的缺如对正常妊娠有着重要的意义。另外,Glycodelin-A具有免疫抑制作用,在胚胎着床及植入期抑制母体对胚胎的免疫排斥反应中发挥重要的作用。Glycodelin-A不仅在维持人类生殖的生理过程中起到重要作用,而且其低表达与某些病理妊娠密切相关。综述其在生殖方面相关作用的研究。

Glycodelin-A and Human Reproduction

Glycodelin-A is a glycoprotein synthesized by endometrium during the secretory phase,which expressed in endometrial glands during early pregnancy.The synthesis of glycodelin-A was regulated by several hormones.With the in-depth study of glycodelin-A,the relationship between glycodelin-A and human reproduction became more and more close.The absence of glycodelin-A during periovulation period was significant for normal pregnancy,with its inhibition for sperm-egg binding.Moreover,glycodelin-A played important ...