原发性肝癌患者血清胰岛素样生长因子Ⅱ和血管内皮生长因子的检测及意义 |
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引用本文: | 张小妹,虞丹丹,黄国永,屠燕钗,李建道,刘保林. 原发性肝癌患者血清胰岛素样生长因子Ⅱ和血管内皮生长因子的检测及意义[J]. 实用医学杂志, 2008, 24(21): 3691-3692 |
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作者姓名: | 张小妹 虞丹丹 黄国永 屠燕钗 李建道 刘保林 |
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作者单位: | 1. 浙江省温州市中心血站,325001 2. 温州医学院第一附属医院,325000 |
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摘 要: | 目的:探讨原发性肝癌(PHC)患者血清胰岛素样生长因子Ⅱ(IGF-Ⅱ)和血管内皮生长因子(VEGF)的表达及意义。方法:分别采用放射免疫分析法及ELISA法检测63例PHC患者(PHC组)、56例肝硬化患者(肝硬化组1和60例正常对照者(对照组)血清IGF-Ⅱ和VEGF含量,并对PHC患者治疗前后的血清IGF-Ⅱ和VEGF含量进行相关性分析。结果:PHC组患者血清IGF-Ⅱ和VEGF的含量显著高于肝硬化组和对照组(P〈0.05);肝硬化组血清1GF-Ⅱ和VEGF的含量显著高于对照组(P〈0.05)。经介入治疗后6个月随访,12例复发者血清IGF-Ⅱ和VEGF含量显著高于51侧未复发者(P〈0.05)。治疗前后IGF-Ⅱ与VEGF均呈显著正相关(r=0.43,0.39,P〈0.05)。结论:IGF-Ⅱ与VEGF可作为肿瘤标记物,两者联合检测有助于提高对PHC的检出率,动态检测二者的水平可为临床肝癌的综合治疗及预后判定提供依据。[著者文摘]
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关 键 词: | 肝肿瘤 胰岛素样生长因子Ⅱ 血管内皮生长因子类 |
收稿时间: | 2008-04-16 |
Detection and significance of serum IGF-Ⅱ and VEGF in primary hepatocarcinoma patients |
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Abstract: | [Abstract] Objective To explore the significance and expression of serum insulin like growth factors Ⅱ(IGF-Ⅱ)and vascular endothelial growth factor(VEGF)in primary hepatocarcinoma(PHC). Methods By using RIA and ELISA, serum IGF-Ⅱ and VEGF levels were determined in 63 patients with PHC, 56 patients with liver cirrhosis and 60 healthy controls. The relationship between IGF-Ⅱ and VEGF were analyzed, before and after treatment. Results The serum IGF-Ⅱ and VEGF levels in PHC group were significantly higher than those in liver cirrhosis group and in healthy control group(P<0.05). The serum IGF-Ⅱ and VEGF levels in liver cirrhosis group were significantly higher than those in healthy control group(P<0.05).6 months later after treatment, the serum IGF-Ⅱ and VEGF levels in the patients without recurrence remained normal(P>0.05). However, the levels in the 12 patients with recurrence returned to those before intervention therapy. Before and after treatment, IGF-Ⅱwere positively correlated in straight line with VEGF(r=0.43,0.39;P<0.05)in PHC. Conclusion Serum IGF-Ⅱ and VEGF can be as tumor marker. The combination detection of serum IGF-Ⅱ and VEGF can improve the detection rates and provide a significant index marker for combined therapy and prognosis in PHC. |
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