Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in Healthy non-HIV-infected people |
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| Authors: | Crispian Scully Stephen R. Porter Luca Di Alberti Mohamed Jalaal Norman Maitland |
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| Affiliation: | Eastman Dental Institute for Oral health Care Sciences, University of London, UK.;Department of Microbiology, Bristol Royal infirmary, Bristol, University of York, York, UK;YCRC Cancer Research Unit, Department of Biology, University of York, York, UK |
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| Abstract: | Epstein-barr Virus (EBV) has been implicated in the pathogenesis of oral hairy leukoplakia (OHL). EBV is normally detected by lesional biopsy. The objectives of this study were to examine oral scrapes containing squamous epithelial cells from healthy non-HIV-infected people with and without clincial lesions of OHL, and from healthy non-HIV-infected controls, for EBV-DNA by the polymerase chain reaction (PCR). EBV-DNA was detected in 65% of HIV-infected individuals it was found as frequently in those without OHL as in those with. Moreover, EBV-DNA was not detected in all HIV-infected individuals, nor in all OHL as in those with. Moreover, EBV-DNA was not detected in all Hiv-infected individuals, nor in all OHL> The results suggest that the presence or absenc e of detectable EBV-DNA in oral scrapes, though a guide, cannot be regarded as absolutely reliable in the diagnosis or exclusion of OHL. |
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| Keywords: | Key words: Cytology Epstein-Barr virus hairy leukoplakia HIV |
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