牛蒡苷元对自发性高血压大鼠的降压及对靶器官的保护作用

目的研究牛蒡苷元（ARC—G）对自发性高血压大鼠（SIqR）和正常Wistar大鼠血压的调节、靶器官的保护作用。方法12周龄的SHRs（280g～320g）40只随机分为牛蒡苷元高、中、低剂量组（100mg／kg、50mg／kg、25mg／kg），硝苯地平（3mg／kg）阳性对照组，溶剂对照组；相应周龄的Wistar大鼠16只，随机分为牛蒡苷元（100mg／kg）和溶剂对照组。所有溶剂均为1％羧甲基纤维素，灌胃给药8周。观察牛蒡苷元对SHR和Wistar大鼠血压、心、肾高血压主要靶器官质量指数的影响。结果牛蒡苷元对各组大鼠体重无影响，但可剂量依赖性地降低SHR大鼠血压；牛蒡苷元和硝苯地平能明显抑制SHR左心室肥厚，SHR各组的SBP和左室质量指数、肾脏质量指数均明显高于同龄Wistar大鼠耿0．01）。给药治疗2周后，与SHR对照组比较ARC—G高中剂量组可明显降低SBP（P〈0．05或尺0．01），可明显降低左室质量指数（P〈0．05或P〈0．01）；对肾脏质量指数无明显影响（P〉0．05）；牛蒡苷元对Wistar大鼠各指标均无明显影响，与对照组相比（P〉0．05）。结论牛蒡苷元对SHR有降压及逆转左心室肥厚的作用。

Hypotensive and target organs protective effects of arctigenin on SHR

Objective To investigate hypotensive and target organs protective effecs of long-term treatment with aretigenin （ARC-G）. Methods Forty 12-week-old male SHR（280-320g） were randomly assigned to five groups （aretigenin 100mg/ kg, arctigenin 50mg/kg, arctigenin 25mg/kg nifedipine3mg/kg, SHR vehicle） and matched Wistar rats were randomly assigned to two groups （Wistar＋aretigeninlO0mg/kg and Wistar vehicle）. All animals were treated for 8 weeks. Systolic blood pressure was determined every other week. Bodyweight was determined every week. Cardiac and renal morphology were examined. Results Chronic arctigenin treatment reduced systolic blood pressure in a dose dependent manner, and significantly reduced left ventricular hypertrophy. The efficianey of arctigenin （50,100mg/kg） is similar to nifedipine. Conclusion Aretigenin can decrease high blood pressure and reverse left ventrieular hypotrophy in SHR.