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Exercise Tolerance in Patients With Ebstein’s Anomaly |
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| Authors: | Susan G. MacLellan-Tobert MD FRCP David J. Driscoll MD Carl D. Mottram RRT Douglas W. Mahoney MS Peter C. Wollan PhD Gordon K. Danielson MD |
| Affiliation: | Susan G. MacLellan-Tobert, MD, FRCP(C), David J. Driscoll, MD, Carl D. Mottram, RRT, Douglas W. Mahoney, MS, Peter C. Wollan, PhD,Gordon K. Danielson, MD |
| Abstract: | Objectives. The purpose of this study was to identify the determinants of exercise tolerance in patients with Ebstein’s anomaly. Background. Patients with Ebstein’s anomaly of the tricuspid valve may have exercise limitation that improves after surgical repair. Methods. One hundred seventeen patients performed cycle ergometry for a total of 124 tests (preoperative test in 76 patients, postoperative test in 23, test but no operation in 18, preoperative and postoperative test in 7). Multiple linear regression analysis was used to identify predictors of maximal oxygen uptake, oxygen saturation and heart rate at peak exercise. Results. Age at the time of exercise ranged from 6 to 60 years (median 15). An atrial septal defect was present in 67 patients (88%) preoperatively. Compared with the preoperative group, the postoperative group had significantly higher maximal oxygen uptake (mean [±SD] 20.5 ± 7.4 vs. 25.3 ± 7.0 ml/kg body weight per min, p = 0.006). Postoperative rest and exercise blood oxygen saturation was higher than that measured preoperatively (p = 0.0001). Six of seven patients tested before and after the operation showed improved exercise tolerance. Preoperatively, major predictors of maximal oxygen uptake were oxygen saturation at rest (p = 0.01) and age (p = 0.0001). Preoperatively, the major predictor of oxygen saturation at peak exercise was rest oxygen saturation (p = 0.0001), and major predictors of peak exercise heart rate were rest heart rate (p = 0.01) and rest oxygen saturation (p = 0.01). In the postoperative group, predictors of maximal oxygen uptake included age at exercise testing, male gender and heart size. Conclusions. Definitive operation for Ebstein’s anomaly results in improved exercise tolerance. Before the operation, rest oxygen saturation is the major predictor of exercise tolerance, oxygen saturation at peak exercise and peak heart rate. Postoperatively, age, gender and heart size influenced maximal oxygen uptake. (J Am Coll Cardiol 1997;29:1615–22) |
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